Dnaaf5 Dynein axonemal assembly factor 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dnaaf5provided by FlyBase
Official Full Name: Dynein axonemal assembly factor 5provided by FlyBase
Primary source: FLYBASE:FBgn0288976
Locus tag: Dmel_CG31320
See related: AllianceGenome:FB:FBgn0288976
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31320; Dmel\CG31320; fried; Heatr2; HEATR2; NEST:bs27f03
Summary: Predicted to enable dynein intermediate chain binding activity. Involved in several processes, including axonemal dynein complex assembly; flagellated sperm motility; and sensory perception of sound. Located in cytoplasm. Is expressed in several structures, including adult head; embryonic head sensory system; mechanosensory neurons; mesoderm; and sensory nervous system primordium. Used to study primary ciliary dyskinesia and primary ciliary dyskinesia 18. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14358356..14361786, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10184078..10187508, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium movement involved in cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outer dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain