U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ir8a Ionotropic receptor 8a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31867, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Ir8aprovided by FlyBase
Official Full Name
Ionotropic receptor 8aprovided by FlyBase
Primary source
FLYBASE:FBgn0052704
Locus tag
Dmel_CG32704
See related
AllianceGenome:FB:FBgn0052704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
8a; CG12122; CG12666; CG32704; CT7438; DmelIR8a; Dmel\CG32704; IR8a
Summary
Enables coreceptor activity and signaling receptor binding activity. Contributes to extracellular phenylacetaldehyde-gated monoatomic ion channel activity and olfactory receptor activity. Involved in several processes, including cellular response to acetate; detection of chemical stimulus involved in sensory perception of smell; and olfactory behavior. Located in dendrite membrane and sensory dendrite. Part of receptor complex. Is expressed in adult antennal lobe glomerulus; adult antennal olfactory receptor neurons; adult antennal sense organ; and antenna. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1) and GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ir8a in Genome Data Viewer
Location:
8D2-8D2; 1-27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9232726..9236585, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9126759..9130618, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 8a Neighboring gene uncharacterized protein Neighboring gene mir-4916 stem loop Neighboring gene multi sex combs Neighboring gene La related protein 7 Neighboring gene almondex

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pheromonal Cues Deposited by Mated Females Convey Social Information about Egg-Laying Sites in Drosophila Melanogaster. Duménil C, et al. J Chem Ecol, 2016 Mar. PMID 26994611, Free PMC Article
  2. Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons of Drosophila melanogaster. Pettersson JH, et al. Front Mol Biosci, 2023. PMID 38344364, Free PMC Article
  3. Odor-identity dependent motor programs underlie behavioral responses to odors. Jung SH, et al. Elife, 2015 Oct 6. PMID 26439011, Free PMC Article
  4. Vibrational Detection of Odorant Functional Groups by Drosophila melanogaster. Maniati K, et al. eNeuro, 2017 Sep-Oct. PMID 29094064, Free PMC Article
  5. Phenylacetaldehyde induced olfactory conditioning in Drosophila melanogaster (Diptera: Drosophilidae) larvae. Ali MZ, et al. J Insect Sci, 2023 Nov 1. PMID 38092368, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IR8a is a subunit that forms a functional olfactory receptor with IR64a in vivo to mediate odor detection
    Title: Ionotropic glutamate receptors IR64a and IR8a form a functional odorant receptor complex in vivo in Drosophila.
  2. IR8a and IR25a are essential for odor-evoked electrophysiological responses in multiple distinct neuron classes.
    Title: Functional architecture of olfactory ionotropic glutamate receptors.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to extracellular ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to extracellular phenylacetaldehyde-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic ion channel activity ISM
Inferred from Sequence Model
more info
 PubMed 
contributes_to olfactory receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to acetate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in olfactory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to acetate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chlorate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sensory dendrite IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ionotropic receptor 8a
Names
CG32704-PA
Ir8a-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9232726..9236585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167185.1 → NP_727328.1  ionotropic receptor 8a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9NA95, Q9W365
    Related
    FBpp0071268, FBtr0071333
    Conserved Domains (2) summary
    cd13717
    Location:383 → 786
    PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:520 → 818
    Lig_chan; Ligand-gated ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W365 Q9W365

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous