Zpr1 Zpr1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zpr1provided by FlyBase
Official Full Name: Zpr1provided by FlyBase
Primary source: FLYBASE:FBgn0030096
Locus tag: Dmel_CG9060
See related: AllianceGenome:FB:FBgn0030096
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9060; Dmel\CG9060
Summary: Predicted to enable protein folding chaperone and translation initiation factor binding activity. Involved in cell surface receptor protein tyrosine kinase signaling pathway and open tracheal system development. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and organism. Orthologous to human ZPR1 (ZPR1 zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9160124..9162090, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9054157..9056123, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

this is the first genetic evidence placing Zpr1 downstream of EGFR signaling, and the first time Zpr1 has been implicated in FGFR signaling
Title: Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein folding chaperone	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lumen formation, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pre-mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain