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Caf1-180 Chromatin assembly factor 1, p180 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31801, updated on 9-Dec-2024

Summary

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Official Symbol
Caf1-180provided by FlyBase
Official Full Name
Chromatin assembly factor 1, p180 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0030054
Locus tag
Dmel_CG12109
See related
AllianceGenome:FB:FBgn0030054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CAF-1 p180; Caf-180; Caf1; caf1-180; CAF1-180; CAF1-p180; CAF1p180; CG12109; dCAF-1-180; dCAF-1-p180; Dmel\CG12109; NURF; p180; P180
Summary
Predicted to contribute to histone binding activity. Involved in several processes, including DNA metabolic process; nucleosome assembly; and response to gamma radiation. Located in nucleus. Part of CAF-1 complex. Is expressed in organism. Human ortholog(s) of this gene implicated in colon cancer; high grade glioma; neuroblastoma; and systemic lupus erythematosus. Orthologous to human CHAF1A (chromatin assembly factor 1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Caf1-180 in Genome Data Viewer
Location:
7F8-7F8; 1-23 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8602137..8606304, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8496170..8500337, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein Neighboring gene ocelliless Neighboring gene rubicon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Tyler JK, et al. Mol Cell Biol, 1996 Nov. PMID 8887645, Free PMC Article
  2. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Tyler JK, et al. Mol Cell Biol, 2001 Oct. PMID 11533245, Free PMC Article
  3. Maintenance of Heterochromatin by the Large Subunit of the CAF-1 Replication-Coupled Histone Chaperone Requires Its Interaction with HP1a Through a Conserved Motif. Roelens B, et al. Genetics, 2017 Jan. PMID 27838630, Free PMC Article
  4. ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization. Horard B, et al. Epigenetics Chromatin, 2018 May 11. PMID 29751847, Free PMC Article
  5. Epigenetic Regulation of Notch Signaling During Drosophila Development. Wei C, et al. Adv Exp Med Biol, 2020. PMID 32060871

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
    Title: Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
  2. In the absence of P180, germline stem cells still harbor stem cell properties but concomitantly express markers of differentiation. In addition, P180-depleted germ cells exhibit elevated levels of DNA damage and de-repression of the transposable I element. These DNA damages activate p53- and Chk2-dependent checkpoints pathways, leading to cell death and female sterility.
    Title: The replicative histone chaperone CAF1 is essential for the maintenance of identity and genome integrity in adult stem cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to histone binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CAF-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAF-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chromatin assembly factor 1, p180 subunit
Names
CAF-1 large subunit
CAF1 large subunit
CG12109-PB
Caf1-180-PB
large subunit of CAF-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8602137..8606304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132267.5 → NP_572495.1  chromatin assembly factor 1, p180 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572495.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3D1
    Related
    FBpp0071172
    Conserved Domains (4) summary
    pfam12253
    Location:770 → 814
    CAF1A; Chromatin assembly factor 1 subunit A
    pfam15539
    Location:947 → 1127
    CAF1-p150_C2; CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
    cd16269
    Location:573 → 584
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:491 → 599
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SWV8 Q8SWV8
Q8T9G1 Q8T9G1
Q9W3D1 Q9W3D1

Gene LinkOut

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