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CG32281 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317953, updated on 9-Dec-2024

Summary

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Official Symbol
CG32281provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0052281
Locus tag
Dmel_CG32281
See related
AllianceGenome:FB:FBgn0052281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12032; Dmel\CG32281
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG32281 in Genome Data Viewer
Location:
63B8-63B8; 3-6 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3169375..3170913)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3169375..3170913)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene rasp Neighboring gene ASCIZ zinc finger protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene myomesin and myosin binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Lee JD, et al. Curr Biol, 2001 Jul 24. PMID 11509241
  2. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Chamoun Z, et al. Science, 2001 Sep 14. PMID 11486055
  3. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
  4. MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. Daneshvar K, et al. Biol Open, 2013 Jan 15. PMID 23336071, Free PMC Article
  5. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Thimgan MS, et al. Sleep, 2015 May 1. PMID 25409104, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG32281-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3169375..3170913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167995.2 → NP_728821.2  uncharacterized protein Dmel_CG32281 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728821.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRE4
    Related
    FBpp0072898
    Conserved Domains (2) summary
    pfam02475
    Location:149 → 353
    Met_10; Met-10+ like-protein
    cl17173
    Location:224 → 313
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IRE4.2 Q8IRE4

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