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l(3)72Dp lethal (3) 72Dp [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317887, updated on 9-Dec-2024

Summary

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Official Symbol
l(3)72Dpprovided by FlyBase
Official Full Name
lethal (3) 72Dpprovided by FlyBase
Primary source
FLYBASE:FBgn0263607
Locus tag
Dmel_CG32155
See related
AllianceGenome:FB:FBgn0263607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32155; CG5082; Dmel\CG32155
Summary
Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in tetrahydrofolylpolyglutamate metabolic process. Predicted to be active in vacuole. Is expressed in adult head. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See l(3)72Dp in Genome Data Viewer
Location:
72D10-72D10; 3-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16234140..16236999)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16227240..16230099)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Programmed Cell Death 5 Neighboring gene Mediator complex subunit 10 Neighboring gene Heat shock protein cognate 20 Neighboring gene lethal (3) 72Dr Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article
  2. Anent the genomics of spermatogenesis in Drosophila melanogaster. Lindsley DL, et al. PLoS One, 2013. PMID 23409089, Free PMC Article
  3. Drosophila Relish Activating lncRNA-CR33942 Transcription Facilitates Antimicrobial Peptide Expression in Imd Innate Immune Response. Zhou H, et al. Front Immunol, 2022. PMID 35720331, Free PMC Article
  4. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
  5. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-glutamyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables omega peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tetrahydrofolylpolyglutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lethal (3) 72Dp
Names
CG32155-PA
l(3)72Dp-PA
NP_730119.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16234140..16236999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168655.3 → NP_730119.1  lethal (3) 72Dp [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730119.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BIC6, Q8IQM9
    Related
    FBpp0075214
    Conserved Domains (2) summary
    cd01747
    Location:28 → 303
    GATase1_Glutamyl_Hydrolase; Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
    pfam07722
    Location:26 → 244
    Peptidase_C26; Peptidase C26
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BIC6 Q5BIC6
Q8IQM9 Q8IQM9

Gene LinkOut

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