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Elo68alpha Elongase 68alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317841, updated on 9-Dec-2024

Summary

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Official Symbol
Elo68alphaprovided by FlyBase
Official Full Name
Elongase 68alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0052072
Locus tag
Dmel_CG32072
See related
AllianceGenome:FB:FBgn0052072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32072; CG6261; Dmel\CG32072; elo68alpha
Summary
Enables fatty acid elongase activity. Involved in fatty acid elongation, unsaturated fatty acid; long-chain fatty acid biosynthetic process; and pheromone biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in corneal dystrophy and spinocerebellar ataxia type 34. Orthologous to human ELOVL4 (ELOVL fatty acid elongase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Elo68alpha in Genome Data Viewer
Location:
68A6-68A6; 3-34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11101875..11103030, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11094975..11096130, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beta-Amyloid precursor protein binding protein 1 Neighboring gene Elongase 68beta Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster. Chertemps T, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360514, Free PMC Article
  2. A new elongase selectively expressed in Drosophila male reproductive system. Chertemps T, et al. Biochem Biophys Res Commun, 2005 Aug 12. PMID 15975553
  3. A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Szafer-Glusman E, et al. Curr Biol, 2008 Sep 23. PMID 18804373, Free PMC Article
  4. The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development. Jung A, et al. J Cell Sci, 2007 Aug 15. PMID 17666430
  5. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Grönke S, et al. Cell Metab, 2005 May. PMID 16054079

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid elongase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acid elongase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid elongase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid elongation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, unsaturated fatty acid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pheromone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
elongase 68alpha
Names
CG32072-PA
Elo68alpha-PA
NP_729666.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11101875..11103030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168440.3 → NP_729666.2  elongase 68alpha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729666.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5JZZ4, Q8IQF0
    Conserved Domains (1) summary
    pfam01151
    Location:23 → 260
    ELO; GNS1/SUR4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JZZ4 Q5JZZ4

Gene LinkOut

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