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CG32026 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317829, updated on 14-Nov-2024

Summary

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Official Symbol
CG32026provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0052026
Locus tag
Dmel_CG32026
See related
AllianceGenome:FB:FBgn0052026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.202; BcDNA:GH12815; Dmel\CG32026
Summary
Predicted to enable isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; dorsal ectoderm; dorsal ectoderm anlage; and embryonic/larval midgut primordium. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG32026 in Genome Data Viewer
Location:
66E1-66E1; 3-27 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8836462..8838843)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8829562..8831943)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene division abnormally delayed Neighboring gene long non-coding RNA:CR45823 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm. Ramesh R, et al. Antioxid Redox Signal, 2023 Jun. PMID 36509450, Free PMC Article
  2. Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1. Sen A, et al. Front Physiol, 2022. PMID 36388112, Free PMC Article
  3. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article
  4. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
  5. Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species. Hagen JFD, et al. Mol Biol Evol, 2021 Jan 23. PMID 32931587, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables isocitrate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isocitrate dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of isocitrate dehydrogenase complex (NAD+) ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG32026-PA
NP_729420.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8836462..8838843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168297.1 → NP_729420.1  uncharacterized protein Dmel_CG32026 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729420.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DN10, Q8T0R3
    Related
    FBpp0076311, FBtr0076584
    Conserved Domains (2) summary
    pfam06473
    Location:281 → 361
    FGF-BP1; FGF binding protein 1 (FGF-BP1)
    cl00445
    Location:382 → 718
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T0R3 Q8T0R3

Gene LinkOut

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