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ttk ttk protein kinase [ Danio rerio (zebrafish) ]

Gene ID: 317763, updated on 9-Dec-2024

Summary

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Official Symbol
ttkprovided by ZNC
Official Full Name
ttk protein kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030123-1
See related
Ensembl:ENSDARG00000041361 AllianceGenome:ZFIN:ZDB-GENE-030123-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ncp; mps1
Summary
Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in negative regulation of exit from mitosis and tissue regeneration. Acts upstream of or within anatomical structure homeostasis; fin regeneration; and meiotic chromosome segregation. Predicted to be active in kinetochore and nucleus. Is expressed in caudal fin and proliferative region. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See ttk in Genome Data Viewer
Location:
chromosome: 16
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (5110455..5143124, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (5210829..5243498, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5Aa Neighboring gene branched chain keto acid dehydrogenase E1 subunit beta Neighboring gene dynactin 3 (p22) Neighboring gene ELOVL fatty acid elongase 4a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Poss KD, et al. Genes Dev, 2004 Jul 1. PMID 15231734, Free PMC Article
  2. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Poss KD, et al. Development, 2002 Nov. PMID 12399306
  3. MicroRNA-133b Negatively Regulates Zebrafish Single Mauthner-Cell Axon Regeneration through Targeting tppp3 in Vivo. Huang R, et al. Front Mol Neurosci, 2017. PMID 29209165, Free PMC Article
  4. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Jopling C, et al. Nature, 2010 Mar 25. PMID 20336145, Free PMC Article
  5. Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin. Bhadra J, et al. Mech Dev, 2015 Nov. PMID 26103547

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the proximal blastema comprises an essential subpopulation of the fin regenerate defined by the induction and function of Mps1
    Title: Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration.
  2. Mps1 is a critical regulator of chromosome number in zebrafish
    Title: Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within female meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein kinase Ttk
Names
mitotic checkpoint serine/threonine-protein kinase Mps1
monopolar spindle 1
monopolar spindle protein 1
nightcap
protein nightcap
NP_778207.1
XP_005157890.1
XP_005157891.1
XP_068069988.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175042.2 → NP_778207.1  dual specificity protein kinase Ttk

    See identical proteins and their annotated locations for NP_778207.1

    Status: PROVISIONAL

    Source sequence(s)
    AF488735
    UniProtKB/Swiss-Prot
    Q7T2A4, Q8AYG3
    Related
    ENSDARP00000121369.1, ENSDART00000131876.2
    Conserved Domains (2) summary
    cd14131
    Location:652 → 917
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:656 → 917
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    5110455..5143124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213887.1 → XP_068069988.1  dual specificity protein kinase Ttk isoform X3

    UniProtKB/Swiss-Prot
    Q7T2A4, Q8AYG3

  2. XM_005157834.5 → XP_005157891.1  dual specificity protein kinase Ttk isoform X1

    UniProtKB/Swiss-Prot
    Q7T2A4, Q8AYG3
    UniProtKB/TrEMBL
    A0A8M2B447, F1R3H9
    Related
    ENSDARP00000060629.6, ENSDART00000060630.8
    Conserved Domains (2) summary
    cd14131
    Location:651 → 916
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:655 → 916
    Pkinase; Protein kinase domain

  3. XM_005157833.5 → XP_005157890.1  dual specificity protein kinase Ttk isoform X2

    UniProtKB/Swiss-Prot
    Q7T2A4, Q8AYG3
    UniProtKB/TrEMBL
    A0A8M2B4P6
    Conserved Domains (2) summary
    cd14131
    Location:652 → 917
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:656 → 917
    Pkinase; Protein kinase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8AYG3.2 GenPept UniProtKB/Swiss-Prot:Q8AYG3

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