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GPBAR1 G protein-coupled bile acid receptor 1 [ Bos taurus (domestic cattle) ]

Gene ID: 317756, updated on 1-Jan-2025

Summary

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Official Symbol
GPBAR1provided by VGNC
Official Full Name
G protein-coupled bile acid receptor 1provided by VGNC
Primary source
VGNC:VGNC:29521
See related
BGD:BT12641; Ensembl:ENSBTAG00000003923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
TGR5
Orthologs
human mouse all
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Genomic context

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See GPBAR1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (106290010..106293245)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) receptor 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene angio associated migratory cell protein Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene PNKD metallo-beta-lactamase domain containing

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. The bile acid receptor TGR5 inhibits platelet activation and thrombus formation. Reusswig F, et al. Platelets, 2024 Dec. PMID 38968449
  2. Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Kida T, et al. Arterioscler Thromb Vasc Biol, 2013 Jul. PMID 23619297
  3. A G protein-coupled receptor responsive to bile acids. Kawamata Y, et al. J Biol Chem, 2003 Mar 14. PMID 12524422
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.
    Title: The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.
  2. TGR5 agonism induces NO production via Akt activation and intracellular Ca(2+) increase in vascular endothelial cells, and this function inhibits monocyte adhesion in response to inflammatory stimuli.
    Title: Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC152072

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled bile acid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled bile acid receptor 1
Names
G protein-coupled receptor TGR5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175049.3 → NP_778219.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_778219.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122824
    UniProtKB/Swiss-Prot
    Q0II36, Q862A9
    Conserved Domains (2) summary
    cd14964
    Location:51 → 72
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:28 → 284
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    106290010..106293245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024999245.2 → XP_024855013.1  G-protein coupled bile acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q0II36, Q862A9
    Related
    ENSBTAP00000005120.3, ENSBTAT00000005120.5
    Conserved Domains (2) summary
    cd14964
    Location:51 → 72
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:28 → 284
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q862A9.1 GenPept UniProtKB/Swiss-Prot:Q862A9

Gene LinkOut

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