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rock2a rho-associated, coiled-coil containing protein kinase 2a [ Danio rerio (zebrafish) ]

Gene ID: 317747, updated on 4-Jan-2025

Summary

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Official Symbol
rock2aprovided by ZNC
Official Full Name
rho-associated, coiled-coil containing protein kinase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030115-3
See related
Ensembl:ENSDARG00000017500 AllianceGenome:ZFIN:ZDB-GENE-030115-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rok2; rock2
Summary
Predicted to enable Rho-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including Wnt signaling pathway, planar cell polarity pathway; gastrulation; and protein catabolic process in the vacuole. Located in plasma membrane. Is expressed in corneal epithelium; fin bud; midbrain hindbrain boundary; otic vesicle; and pharyngeal arch 3-7. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See rock2a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (32815240..32899667, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (32684793..32768597, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene sine oculis binding protein homolog (Drosophila) a Neighboring gene solute carrier family 66 member 3 Neighboring gene ciliary microtubule inner protein 5 Neighboring gene uncharacterized LOC103912024

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity. Lisowska J, et al. J Cell Sci, 2018 Aug 13. PMID 30030370
  2. Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina. Lahne M, et al. J Neurosci, 2015 Nov 25. PMID 26609156, Free PMC Article
  3. Fgfr-Ras-MAPK signaling is required for apical constriction via apical positioning of Rho-associated kinase during mechanosensory organ formation. Harding MJ, et al. Development, 2012 Sep. PMID 22833124, Free PMC Article
  4. Yolk syncytial layer formation is a failure of cytokinesis mediated by Rock1 function in the early zebrafish embryo. Chu LT, et al. Biol Open, 2012 Aug 15. PMID 23213468, Free PMC Article
  5. Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow. Blaser H, et al. Dev Cell, 2006 Nov. PMID 17084355

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings of the present study indicate that miR-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a.
    Title: miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish.
  2. Double knockdown of rock2a disrupted interkinetic nuclear migration in the retina.
    Title: Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina.
  3. Data show that Rock2 acts as a negative regulator of the TGFbeta signaling pathway.
    Title: Rock2 controls TGFbeta signaling and inhibits mesoderm induction in zebrafish embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mediolateral intercalation IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within mesodermal cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within protein catabolic process in the vacuole IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho-associated protein kinase 2
Names
rho-associated, coiled-coil containing protein kinase 2
NP_777288.1
XP_068081021.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174863.3 → NP_777288.1  rho-associated protein kinase 2

    See identical proteins and their annotated locations for NP_777288.1

    Status: VALIDATED

    Source sequence(s)
    CR936241
    UniProtKB/TrEMBL
    A0A8N7UZU0, Q90Y37
    Related
    ENSDARP00000122621.1, ENSDART00000133882.3
    Conserved Domains (7) summary
    cd11638
    Location:491 → 557
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:78 → 340
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:1250 → 1304
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1141 → 1246
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:25 → 403
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    pfam08912
    Location:965 → 1032
    Rho_Binding; Rho Binding
    pfam15450
    Location:431 → 1028
    DUF4631; Domain of unknown function (DUF4631)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    32815240..32899667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224920.1 → XP_068081021.1  rho-associated protein kinase 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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