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Baz2b bromodomain adjacent to zinc finger domain, 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 317627, updated on 2-Nov-2024

Summary

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Official Symbol
Baz2bprovided by RGD
Official Full Name
bromodomain adjacent to zinc finger domain, 2Bprovided by RGD
Primary source
RGD:1309801
See related
EnsemblRapid:ENSRNOG00000056984 AllianceGenome:RGD:1309801
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in chromatin and nucleus. Orthologous to human BAZ2B (bromodomain adjacent to zinc finger domain 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 138.7), Kidney (RPKM 118.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Baz2b in Genome Data Viewer
Location:
3q21
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64792984..65034547, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44384282..44681619, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45968845..46286915, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene uncharacterized LOC134486097 Neighboring gene uncharacterized LOC108350580 Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene ADP-ribosylation factor 4, pseudogene 1 Neighboring gene uncharacterized LOC120101908 Neighboring gene RNA, U6 small nuclear 22 Neighboring gene membrane associated ring-CH-type finger 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bromodomain adjacent to zinc finger domain protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108260.1 → NP_001101730.1  bromodomain adjacent to zinc finger domain protein 2B

    See identical proteins and their annotated locations for NP_001101730.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473983
    UniProtKB/TrEMBL
    A0A0G2K175, A0A0G2K535, A6JF71
    Related
    ENSRNOP00000071727.2, ENSRNOT00000081302.4
    Conserved Domains (7) summary
    cd05503
    Location:2088 → 2184
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1074 → 1137
    DDT; domain in different transcription and chromosome remodeling factors
    cd15630
    Location:1955 → 2003
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam13868
    Location:832 → 1047
    TPH; Trichohyalin-plectin-homology domain
    pfam15612
    Location:1178 → 1218
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:1358 → 1390
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl00110
    Location:755 → 824
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    64792984..65034547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284041.1 → XP_063140111.1  bromodomain adjacent to zinc finger domain protein 2B isoform X26

  2. XM_063284024.1 → XP_063140094.1  bromodomain adjacent to zinc finger domain protein 2B isoform X15

    Related
    ENSRNOP00000098364.2, ENSRNOT00000120739.2

  3. XM_063284046.1 → XP_063140116.1  bromodomain adjacent to zinc finger domain protein 2B isoform X31

  4. XM_063284011.1 → XP_063140081.1  bromodomain adjacent to zinc finger domain protein 2B isoform X6

  5. XM_063284045.1 → XP_063140115.1  bromodomain adjacent to zinc finger domain protein 2B isoform X30

  6. XM_063284009.1 → XP_063140079.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

  7. XM_063284040.1 → XP_063140110.1  bromodomain adjacent to zinc finger domain protein 2B isoform X25

    Related
    ENSRNOP00000098366.2, ENSRNOT00000120741.2

  8. XM_063284038.1 → XP_063140108.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

  9. XM_063284022.1 → XP_063140092.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

  10. XM_063284036.1 → XP_063140106.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

    Related
    ENSRNOP00000098363.2, ENSRNOT00000120738.2

  11. XM_063284033.1 → XP_063140103.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

  12. XM_063284018.1 → XP_063140088.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

  13. XM_063284030.1 → XP_063140100.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

  14. XM_063284047.1 → XP_063140117.1  bromodomain adjacent to zinc finger domain protein 2B isoform X32

  15. XM_063284005.1 → XP_063140075.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  16. XM_063284031.1 → XP_063140101.1  bromodomain adjacent to zinc finger domain protein 2B isoform X20

  17. XM_063284028.1 → XP_063140098.1  bromodomain adjacent to zinc finger domain protein 2B isoform X18

    UniProtKB/TrEMBL
    A0A8I6A6K9

  18. XM_039105324.2 → XP_038961252.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

    UniProtKB/TrEMBL
    A0A0G2K535
    Conserved Domains (7) summary
    cd05503
    Location:1994 → 2090
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    PTZ00121
    Location:734 → 957
    PTZ00121; MAEBL; Provisional
    smart00571
    Location:980 → 1043
    DDT; domain in different transcription and chromosome remodeling factors
    cd15630
    Location:1861 → 1909
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam15612
    Location:1084 → 1124
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:1264 → 1296
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl00110
    Location:659 → 728
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

  19. XM_063284014.1 → XP_063140084.1  bromodomain adjacent to zinc finger domain protein 2B isoform X9

  20. XM_063284013.1 → XP_063140083.1  bromodomain adjacent to zinc finger domain protein 2B isoform X8

  21. XM_063284012.1 → XP_063140082.1  bromodomain adjacent to zinc finger domain protein 2B isoform X7

  22. XM_063284017.1 → XP_063140087.1  bromodomain adjacent to zinc finger domain protein 2B isoform X12

  23. XM_063284008.1 → XP_063140078.1  bromodomain adjacent to zinc finger domain protein 2B isoform X4

  24. XM_063284016.1 → XP_063140086.1  bromodomain adjacent to zinc finger domain protein 2B isoform X11

  25. XM_063284004.1 → XP_063140074.1  bromodomain adjacent to zinc finger domain protein 2B isoform X2

    UniProtKB/TrEMBL
    A0A0G2K175, A6JF71

  26. XM_063284032.1 → XP_063140102.1  bromodomain adjacent to zinc finger domain protein 2B isoform X21

  27. XM_063284015.1 → XP_063140085.1  bromodomain adjacent to zinc finger domain protein 2B isoform X10

  28. XM_063283999.1 → XP_063140069.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

  29. XM_063284025.1 → XP_063140095.1  bromodomain adjacent to zinc finger domain protein 2B isoform X16

  30. XM_063284010.1 → XP_063140080.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

  31. XM_063284039.1 → XP_063140109.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

    Related
    ENSRNOP00000087832.3, ENSRNOT00000110670.3

  32. XM_063284023.1 → XP_063140093.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

  33. XM_063284037.1 → XP_063140107.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

    Related
    ENSRNOP00000098362.2, ENSRNOT00000120737.2

  34. XM_063284034.1 → XP_063140104.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

  35. XM_063284019.1 → XP_063140089.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

  36. XM_063284029.1 → XP_063140099.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

  37. XM_063284006.1 → XP_063140076.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  38. XM_063284026.1 → XP_063140096.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

  39. XM_063284000.1 → XP_063140070.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

  40. XM_063284021.1 → XP_063140091.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

  41. XM_063284002.1 → XP_063140072.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

  42. XM_063284020.1 → XP_063140090.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

  43. XM_063284001.1 → XP_063140071.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

  44. XM_063284035.1 → XP_063140105.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

  45. XM_063284007.1 → XP_063140077.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  46. XM_063284027.1 → XP_063140097.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

  47. XM_063284003.1 → XP_063140073.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

  48. XM_063284044.1 → XP_063140114.1  bromodomain adjacent to zinc finger domain protein 2B isoform X29

  49. XM_063284043.1 → XP_063140113.1  bromodomain adjacent to zinc finger domain protein 2B isoform X28

  50. XM_063284042.1 → XP_063140112.1  bromodomain adjacent to zinc finger domain protein 2B isoform X27

Nucleotide Protein Strain
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