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Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317546, updated on 27-Nov-2024

Summary

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Official Symbol
Tab3provided by RGD
Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by RGD
Primary source
RGD:1594527
See related
EnsemblRapid:ENSRNOG00000003643 AllianceGenome:RGD:1594527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in defense response to bacterium; non-canonical NF-kappaB signal transduction; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in endoplasmic reticulum. Orthologous to human TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 46.6), Kidney (RPKM 38.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tab3 in Genome Data Viewer
Location:
Xq21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (53923473..53995777)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (49972414..50044658)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (54035958..54090282)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ferritin, heavy polypeptide-like 17, member A Neighboring gene xanthine dehydrogenase, pseudogene 1 Neighboring gene glycerol kinase Neighboring gene replication protein A 14 kDa subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Up-Regulation of TAB3 Is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage. Zhu L, et al. Cell Mol Neurobiol, 2017 May. PMID 27352012
  2. miR-23b/TAB3/NF-κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid. Roshan-Milani S, et al. Biofactors, 2022 Jul. PMID 35201648
  3. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. Brown J, et al. J Dent Res, 2011 Apr. PMID 20940366, Free PMC Article
  4. Tripartite motif 38 attenuates cardiac fibrosis after myocardial infarction by suppressing TAK1 activation via TAB2/3 degradation. Lu Z, et al. iScience, 2022 Aug 19. PMID 35982795, Free PMC Article
  5. Expanding role of ubiquitination in NF-κB signaling. Liu S, et al. Cell Res, 2011 Jan. PMID 21135871, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-23b/TAB3/NF-kappaB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid.
    Title: miR-23b/TAB3/NF-κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid.
  2. TAB3 level was accompanied by the increased expression of active-caspase-3, active-caspase-8, and decreased expression of Bcl-2
    Title: Up-Regulation of TAB3 Is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TGF-beta activated kinase 1 (MAP3K7) binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Names
TGF-beta activated kinase 1 and MAP3K7 binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433003.1 → NP_001419932.1  TGF-beta activated kinase 1 (MAP3K7) binding protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    F1M1D2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    53923473..53995777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100565.2 → XP_038956493.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

    Related
    ENSRNOP00000004854.8, ENSRNOT00000004854.9
    Conserved Domains (3) summary
    smart00547
    Location:690 → 712
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:690 → 709
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  2. XM_039100567.2 → XP_038956495.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

    UniProtKB/TrEMBL
    A6IPW0, F1M1D2
    Conserved Domains (3) summary
    smart00547
    Location:690 → 712
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:690 → 709
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  3. XM_039100564.1 → XP_038956492.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABN5, A6IPW0
    Related
    ENSRNOP00000089411.1, ENSRNOT00000100917.2
    Conserved Domains (3) summary
    smart00547
    Location:700 → 722
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:700 → 719
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl21463
    Location:37 → 60
    UBA_like_SF; UBA domain-like superfamily

RNA

  1. XR_005498528.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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