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Msl3 MSL complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317464, updated on 27-Nov-2024

Summary

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Symbol
Msl3provided by RGD
Full Name
MSL complex subunit 3provided by RGD
Primary source
RGD:1549763
See related
EnsemblRapid:ENSRNOG00000004016 AllianceGenome:RGD:1549763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Msl31; Msl3l1
Summary
Predicted to enable DNA binding activity; histone reader activity; and methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of MSL complex and NuA4 histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to human MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 190.7), Heart (RPKM 188.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Msl3 in Genome Data Viewer
Location:
Xq13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (29210388..29228060)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (25638029..25655698)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (27015826..27033562)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 6 Neighboring gene uncharacterized LOC120099231 Neighboring gene uncharacterized LOC120099222 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene FERM and PDZ domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Basilicata MF, et al. Nat Genet, 2018 Oct. PMID 30224647, Free PMC Article
  2. Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. Kim D, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20657587, Free PMC Article
  3. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MSL complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
male-specific lethal 3 homolog
Names
male-specific lethal-3 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014111.2 → NP_001014133.1  male-specific lethal 3 homolog isoform 1

    See identical proteins and their annotated locations for NP_001014133.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    Q5RJQ2
    Related
    ENSRNOP00000061187.3, ENSRNOT00000065814.3
    Conserved Domains (2) summary
    pfam05712
    Location:107 → 447
    MRG; MRG
    pfam12258
    Location:254 → 353
    Microcephalin; Microcephalin protein

  2. NM_001434212.1 → NP_001421141.1  male-specific lethal 3 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434213.1 → NP_001421142.1  male-specific lethal 3 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  4. NM_001434214.1 → NP_001421143.1  male-specific lethal 3 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  5. NM_001434215.1 → NP_001421144.1  male-specific lethal 3 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    29210388..29228060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017602075.3 → XP_017457564.1  male-specific lethal 3 homolog isoform X8

  2. XM_063280078.1 → XP_063136148.1  male-specific lethal 3 homolog isoform X10

    UniProtKB/TrEMBL
    F7FM67

  3. XM_017602077.3 → XP_017457566.1  male-specific lethal 3 homolog isoform X9

  4. XM_063280079.1 → XP_063136149.1  male-specific lethal 3 homolog isoform X11

  5. XM_008773169.4 → XP_008771391.2  male-specific lethal 3 homolog isoform X1

  6. XM_006256835.5 → XP_006256897.3  male-specific lethal 3 homolog isoform X2

  7. XM_006256839.5 → XP_006256901.3  male-specific lethal 3 homolog isoform X4

  8. XM_006256836.5 → XP_006256898.3  male-specific lethal 3 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I6A9H7
    Related
    ENSRNOP00000090151.1, ENSRNOT00000113748.2

  9. XM_063280077.1 → XP_063136147.1  male-specific lethal 3 homolog isoform X7

  10. XM_039099827.2 → XP_038955755.1  male-specific lethal 3 homolog isoform X5

    Conserved Domains (2) summary
    pfam05712
    Location:161 → 510
    MRG
    cl28914
    Location:29 → 76
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  11. XM_039099828.2 → XP_038955756.1  male-specific lethal 3 homolog isoform X6

    Conserved Domains (2) summary
    pfam05712
    Location:160 → 509
    MRG
    cl28914
    Location:29 → 75
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  12. XM_063280080.1 → XP_063136150.1  male-specific lethal 3 homolog isoform X12

  13. XM_063280081.1 → XP_063136151.1  male-specific lethal 3 homolog isoform X13

RNA

  1. XR_005497991.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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