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Smox - Smad on X

Enables chromatin DNA binding activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; imaginal disc-derived wing morphogenesis; and nervous system development. Located in cytosol and nucleus. Part of heteromeric SMAD protein complex. Is expressed in several structures, including embryonic anal pad; embryonic/larval midgut; ganglia; germline cell; and larval muscle cell. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome (multiple); Lynch syndrome; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human SMAD2 (SMAD family member 2) and SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Smox

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Species Gene Architecture aa