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Ldsdh1 Lipid droplet subset dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31726, updated on 4-Jan-2025

Summary

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Official Symbol
Ldsdh1provided by FlyBase
Official Full Name
Lipid droplet subset dehydrogenase 1provided by FlyBase
Primary source
FLYBASE:FBgn0029994
Locus tag
Dmel_CG2254
See related
AllianceGenome:FB:FBgn0029994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2254; Dmel\CG2254
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Located in endoplasmic reticulum and lipid droplet. Is expressed in adult head; adult heart; embryonic/larval anterior midgut; embryonic/larval corpus allatum; and embryonic/larval fat body. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13); and RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ldsdh1 in Genome Data Viewer
Location:
7D5-7D5; 1-22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8078350..8081605, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7972383..7975638, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Upf2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45535 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin conjugating enzyme E2H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting of the Drosophila protein CG2254/Ldsdh1 to a subset of lipid droplets. Thul PJ, et al. J Cell Sci, 2017 Sep 15. PMID 28775149
  2. PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila. Beller M, et al. Cell Metab, 2010 Nov 3. PMID 21035762
  3. The contribution of the Drosophila model to lipid droplet research. Kühnlein RP. Prog Lipid Res, 2011 Oct. PMID 21620889
  4. The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains. Santana JF, et al. Cell Rep, 2020 Mar 10. PMID 32160531, Free PMC Article
  5. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lipid droplet subset dehydrogenase 1
Names
CG2254-PA
Ldsdh1-PA
NP_572436.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8078350..8081605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132208.2 → NP_572436.1  lipid droplet subset dehydrogenase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572436.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWZ9, Q9W3K9
    Related
    FBpp0071071
    Conserved Domains (2) summary
    pfam00106
    Location:59 → 248
    adh_short; short chain dehydrogenase
    cl21454
    Location:60 → 287
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SWZ9 Q8SWZ9
Q9W3K9 Q9W3K9

Gene LinkOut

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