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Upf2 Upf2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31724, updated on 9-Dec-2024

Summary

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Official Symbol
Upf2provided by FlyBase
Official Full Name
Upf2provided by FlyBase
Primary source
FLYBASE:FBgn0029992
Locus tag
Dmel_CG2253
See related
AllianceGenome:FB:FBgn0029992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2253; Dmel\CG2253; smg-3; upf2; UPF2
Summary
Predicted to enable RNA binding activity. Involved in neuromuscular synaptic transmission; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and synapse organization. Predicted to be part of exon-exon junction complex. Predicted to be active in cytoplasm. Is expressed in adult heart. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Upf2 in Genome Data Viewer
Location:
7D5-7D5; 1-22 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8070244..8075466, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7964277..7969499, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) homeotic Neighboring gene myospheroid Neighboring gene uncharacterized protein Neighboring gene Lipid droplet subset dehydrogenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. Ponting CP. Trends Biochem Sci, 2000 Sep. PMID 10973054
  2. Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response. Johnson JL, et al. Neuron, 2019 Nov 20. PMID 31585809, Free PMC Article
  3. Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration. Zuniga G, et al. Alzheimers Dement, 2023 Feb. PMID 35416419, Free PMC Article
  4. In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila. Chapin A, et al. G3 (Bethesda), 2014 Mar 20. PMID 24429422, Free PMC Article
  5. Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Nelson JO, et al. Genetics, 2018 Aug. PMID 29903866, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our findings indicate that impaired UPF2-dependent nonsense-mediated decay leads to neurodevelopmental dysfunction
    Title: Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response.
  2. the lethality of upf1 and upf2 mutants is not due to disrupting their roles during Nonsense-mediated RNA decay (NMD) -independent processes, but to their function in the degradation of specific mRNAs by the NMD pathway.
    Title: Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Upf2
Names
CG2253-PA
Upf2-PA
up-frameshift suppressor 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8070244..8075466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132206.3 → NP_572434.1  Upf2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572434.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3L1
    Related
    FBpp0071072
    Conserved Domains (3) summary
    smart00543
    Location:518 → 701
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:716 → 934
    MIF4G; MIF4G domain
    pfam04050
    Location:980 → 1192
    Upf2; Up-frameshift suppressor 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YU82 Q7YU82
Q9W3L1 Q9W3L1

Gene LinkOut

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