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Uprt uracil phosphoribosyltransferase homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 317237, updated on 9-Dec-2024

Summary

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Official Symbol
Uprtprovided by RGD
Official Full Name
uracil phosphoribosyltransferase homologprovided by RGD
Primary source
RGD:1564806
See related
EnsemblRapid:ENSRNOG00000063275 AllianceGenome:RGD:1564806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564806
Summary
Predicted to enable ribosylnicotinamide kinase activity. Involved in several processes, including UMP biosynthetic process; lactation; and response to insulin. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 208.9), Kidney (RPKM 94.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uprt in Genome Data Viewer
Location:
Xq22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (73582267..73612488)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (69516573..69546811)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (75382553..75408541)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene neurite extension and migration factor Neighboring gene microRNA 672 Neighboring gene ATP binding cassette subfamily B member 7 Neighboring gene zinc finger DHHC-type palmitoyltransferase 15 Neighboring gene microRNA 3559 Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of purine and pyrimidine metabolism by insulin and by resistance to tiazofurin. Weber G, et al. Adv Enzyme Regul, 1985. PMID 3907307
  2. Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes. Kunjara S, et al. Biochem Med Metab Biol, 1992 Dec. PMID 1476792
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosylnicotinamide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lactation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uracil phosphoribosyltransferase homolog
Names
uracil phosphoribosyltransferase (FUR1) homolog
XP_228538.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432983.1 → NP_001419912.1  uracil phosphoribosyltransferase homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6G3Q5, A6IV17

  2. NM_001432984.1 → NP_001419913.1  uracil phosphoribosyltransferase homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6G3Q5, A6IV17

  3. NM_001432985.1 → NP_001419914.1  uracil phosphoribosyltransferase homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    73582267..73612488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_228538.11 → XP_228538.3  uracil phosphoribosyltransferase homolog

    Related
    ENSRNOP00000078739.1, ENSRNOT00000100029.2
    Conserved Domains (1) summary
    pfam14681
    Location:118 → 308
    UPRTase; Uracil phosphoribosyltransferase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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