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Ubr3 Ubr3 ubiquitin ligase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31713, updated on 9-Dec-2024

Summary

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Official Symbol
Ubr3provided by FlyBase
Official Full Name
Ubr3 ubiquitin ligaseprovided by FlyBase
Primary source
FLYBASE:FBgn0260970
Locus tag
Dmel_CG42593
See related
AllianceGenome:FB:FBgn0260970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3
Old locus tag
Dmel_CG1530; Dmel_CG1531
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including positive regulation of smoothened signaling pathway; protein ubiquitination; and sensory perception of sound. Located in cytosol. Is active in neuronal cell body. Is expressed in several structures, including Johnston organ; eye disc; eye disc morphogenetic furrow; scolopidial cilium; and segment of antenna. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ubr3 in Genome Data Viewer
Location:
7C8-7D1; 1-21 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7935896..7953883)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7829929..7847916)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S14a Neighboring gene Ribosomal protein S14b Neighboring gene orion Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45620 Neighboring gene swiss cheese

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning. Ray S, et al. Elife, 2019 Mar 21. PMID 30896406, Free PMC Article
  2. Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila. Huang Q, et al. Cell Death Differ, 2014 Dec. PMID 25146930, Free PMC Article
  3. Pri sORF peptides induce selective proteasome-mediated protein processing. Zanet J, et al. Science, 2015 Sep 18. PMID 26383956
  4. Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis. Bohère J, et al. Nat Commun, 2018 Nov 30. PMID 30504772, Free PMC Article
  5. Pri peptides temporally coordinate transcriptional programs during epidermal differentiation. Gallois M, et al. Sci Adv, 2024 Feb 9. PMID 38335295, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors show that a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubiquitin-ligase Ubr3 and transcription factor Shavenbaby (Svb), represents an ancient developmental module required for early insect embryo patterning.
    Title: The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning.
  2. Ubr3 negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans.
    Title: The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
  3. We identified Ubr3, an E3 ubiquitin ligase, as a novel, positive regulator of Hh signaling in Drosophila and vertebrates. Hh signaling regulates the Ubr3-mediated poly-ubiquitination and degradation of Cos2, a central component of Hh signaling. In developing Drosophila eye discs, loss of ubr3 leads to a delayed differentiation of photoreceptors and a reduction in Hh signaling.
    Title: Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
  4. Ubr3 interacts with DIAP1 and positively regulates DIAP1 activity, possibly by maintaining its active conformation in the apoptosis pathway.
    Title: Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal cell body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubr3 ubiquitin ligase
Names
CG42593-PA
CG42593-PB
CG42593-PC
Ubr3-PA
Ubr3-PB
Ubr3-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7935896..7953883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132200.4 → NP_572428.3  Ubr3 ubiquitin ligase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572428.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PGM3, Q9W3M3
    Conserved Domains (3) summary
    pfam02207
    Location:224 → 291
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    cd16483
    Location:1513 → 1651
    RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
    cl25742
    Location:1413 → 1486
    ERM; Ezrin/radixin/moesin family

  2. NM_001272388.1 → NP_001259317.1  Ubr3 ubiquitin ligase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259317.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDZ8
    Conserved Domains (2) summary
    pfam02050
    Location:1410 → 1477
    FliJ; Flagellar FliJ protein
    pfam02207
    Location:224 → 291
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  3. NM_001272389.1 → NP_001259318.1  Ubr3 ubiquitin ligase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259318.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W3M3
    Conserved Domains (2) summary
    pfam02050
    Location:1410 → 1477
    FliJ; Flagellar FliJ protein
    pfam02207
    Location:224 → 291
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDZ8 M9PDZ8
Q9W3M3.4 Q9W3M3

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