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p115 p115 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31698, updated on 9-Dec-2024

Summary

Official Symbol
p115provided by FlyBase
Official Full Name
p115provided by FlyBase
Primary source
FLYBASE:FBgn0040087
Locus tag
Dmel_CG1422
See related
AllianceGenome:FB:FBgn0040087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1422; Dmel\CG1422; dp115; l(1)G0306
Summary
Involved in several processes, including male germ-line stem cell population maintenance; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of imaginal disc-derived wing size. Located in Golgi stack; cytosol; and endoplasmic reticulum. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; embryonic/larval midgut primordium; and gut section. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See p115 in Genome Data Viewer
Location:
7C2-7C2; 1-21 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7894031..7896991)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7788064..7791024)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nek2 Neighboring gene NADH dehydrogenase (ubiquinone) MNLL subunit Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Ribosomal protein S6

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Golgi vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in male germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of imaginal disc-derived wing size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle fusion with Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
p115
Names
CG1422-PA
CG1422-PB
p115-PA
p115-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7894031..7896991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298063.1NP_001284992.1  p115, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284992.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFR8, Q9W3N6
    Conserved Domains (2) summary
    pfam04869
    Location:354632
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam04871
    Location:690832
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
  2. NM_132189.3NP_572417.1  p115, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572417.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFR8, Q9W3N6
    Related
    FBpp0071045
    Conserved Domains (2) summary
    pfam04869
    Location:354632
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam04871
    Location:690832
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region