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Ir7a Ionotropic receptor 7a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31686, updated on 4-Jan-2025

Summary

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Official Symbol
Ir7aprovided by FlyBase
Official Full Name
Ionotropic receptor 7aprovided by FlyBase
Primary source
FLYBASE:FBgn0029961
Locus tag
Dmel_CG12663
See related
AllianceGenome:FB:FBgn0029961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
7a; CG12663; DmelIR7a; Dmel\CG12663; IR7a
Summary
Predicted to enable ligand-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in membrane. Is expressed in several structures, including adult pharynx; gustatory receptor neurons; labellum; larval gnathal ganglion; and organism subdivision. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ir7a in Genome Data Viewer
Location:
7B8-7B8; 1-20 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7764982..7766826)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7659015..7660859)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rab39 Neighboring gene Translocase of outer membrane 40 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Taste coding of heavy metal ion-induced avoidance in Drosophila. Li X, et al. iScience, 2023 May 19. PMID 37128604, Free PMC Article
  2. Soft Selective Sweep on Chemosensory Genes Correlates with Ancestral Preference for Toxic Noni in a Specialist Drosophila Population. Ferreira EA, et al. Genes (Basel), 2020 Dec 29. PMID 33383708, Free PMC Article
  3. The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus. Loppin B, et al. Nature, 2005 Oct 27. PMID 16251970
  4. A molecular and neuronal basis for amino acid sensing in the Drosophila larva. Croset V, et al. Sci Rep, 2016 Dec 16. PMID 27982028, Free PMC Article
  5. Tastant-receptor interactions: insights from the fruit fly. Arntsen C, et al. Front Nutr, 2024. PMID 38665300, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated monoatomic ion channel activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of taste IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
ionotropic receptor 7a
Names
CG12663-PA
Ir7a-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7764982..7766826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132178.1 → NP_572406.1  ionotropic receptor 7a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572406.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3P8
    Related
    FBpp0071032, FBtr0071075
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3P8 Q9W3P8

Gene LinkOut

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