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rumpel rumpel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31674, updated on 9-Dec-2024

Summary

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Official Symbol
rumpelprovided by FlyBase
Official Full Name
rumpelprovided by FlyBase
Primary source
FLYBASE:FBgn0029950
Locus tag
Dmel_CG9657
See related
AllianceGenome:FB:FBgn0029950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg9657; CG9657; Dmel\CG9657; dSLC5A9
Summary
Enables solute:sodium symporter activity. Involved in transmembrane transport. Is active in plasma membrane. Is expressed in adult head; adult main segment of Malpighian tubule; ensheathing glial cell; larval ventral nerve cord; and lateral cord neurons. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See rumpel in Genome Data Viewer
Location:
7B2-7B2; 1-20 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7418594..7422142)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7312627..7316175)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Social reprogramming in ants induces longevity-associated glia remodeling. Sheng L, et al. Sci Adv, 2020 Aug. PMID 32875108, Free PMC Article
  2. Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli. Wu B, et al. Proc Natl Acad Sci U S A, 2017 Jul 18. PMID 28674010, Free PMC Article
  3. Developmental neural activity requires neuron-astrocyte interactions. Bajar BT, et al. Dev Neurobiol, 2022 Apr. PMID 35225404, Free PMC Article
  4. The glia of the adult Drosophila nervous system. Kremer MC, et al. Glia, 2017 Apr. PMID 28133822, Free PMC Article
  5. Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells. Yildirim K, et al. Biol Open, 2022 Jan 15. PMID 34897385, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables solute:sodium symporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rumpel
Names
CG9657-PA
CG9657-PB
rumpel-PA
rumpel-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7418594..7422142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298054.1 → NP_001284983.1  rumpel, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284983.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSS3, Q9W3R0
    Conserved Domains (1) summary
    cd11492
    Location:16 → 554
    SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain

  2. NM_132169.3 → NP_572397.1  rumpel, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572397.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSS3, Q9W3R0
    Related
    FBpp0071015
    Conserved Domains (1) summary
    cd11492
    Location:16 → 554
    SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSS3 Q8MSS3
Q9W3R0 Q9W3R0

Gene LinkOut

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