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xit xiantuan [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31623, updated on 9-Dec-2024

Summary

Official Symbol
xitprovided by FlyBase
Official Full Name
xiantuanprovided by FlyBase
Primary source
FLYBASE:FBgn0029906
Locus tag
Dmel_CG4542
See related
AllianceGenome:FB:FBgn0029906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Alg8; CG4542; dAlg8; Dalg8; Dmel\CG4542; Xit
Summary
Predicted to enable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Involved in apical constriction involved in gastrulation; germ-band extension; and protein glycosylation. Located in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease 3. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See xit in Genome Data Viewer
Location:
6D3-6D3; 1-18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6821016..6822840)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6715049..6716873)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene inactive Neighboring gene Nuclear factor Y-box C Neighboring gene Ataxin 1 Neighboring gene no-on-and-no-off transient C Neighboring gene muscarinic Acetylcholine Receptor, C-type

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apical constriction involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in germ-band extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
xiantuan
Names
CG4542-PA
xit-PA
NP_572355.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6821016..6822840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132127.4NP_572355.1  xiantuan [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572355.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058Z6, Q9W3V8
    Related
    FBpp0070931
    Conserved Domains (1) summary
    pfam03155
    Location:12478
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family