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Cul9 cullin 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316228, updated on 9-Dec-2024

Summary

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Official Symbol
Cul9provided by RGD
Official Full Name
cullin 9provided by RGD
Primary source
RGD:1562008
See related
EnsemblRapid:ENSRNOG00000018372 AllianceGenome:RGD:1562008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Parc; RGD1562008
Summary
Predicted to enable transferase activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Predicted to be involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Predicted to be located in cytosol. Predicted to be part of cullin-RING ubiquitin ligase complex. Orthologous to human CUL9 (cullin 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 42.7), Brain (RPKM 41.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cul9 in Genome Data Viewer
Location:
9q12
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21933699..21977145)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14435948..14479552)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16747449..16844033)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094784 Neighboring gene serum response factor Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene tau tubulin kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Li Z, et al. Mol Cell, 2014 Jun 5. PMID 24793696, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cullin-9
Names
p53-associated parkin-like cytoplasmic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191582.4 → NP_001178511.2  cullin-9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    Conserved Domains (8) summary
    smart00647
    Location:2134 → 2196
    IBR; In Between Ring fingers
    cd00162
    Location:2063 → 2113
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl02148
    Location:1159 → 1289
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:1585 → 1804
    Cullin; Cullin family
    pfam01485
    Location:2227 → 2262
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366 → 440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl11186
    Location:1856 → 1936
    Cullin_Nedd8; Cullin protein neddylation domain
    cl17238
    Location:2062 → 2113
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    21933699..21977145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083508.2 → XP_038939436.1  cullin-9 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K652
    Related
    ENSRNOP00000073679.2, ENSRNOT00000080815.3
    Conserved Domains (8) summary
    smart00647
    Location:2162 → 2224
    IBR; In Between Ring fingers
    cd00162
    Location:2091 → 2141
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl02148
    Location:1159 → 1289
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:1585 → 1832
    Cullin; Cullin family
    pfam01485
    Location:2255 → 2290
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366 → 440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl11186
    Location:1884 → 1964
    Cullin_Nedd8; Cullin protein neddylation domain
    cl17238
    Location:2090 → 2141
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_039083509.2 → XP_038939437.1  cullin-9 isoform X2

    Conserved Domains (8) summary
    smart00647
    Location:2162 → 2224
    IBR; In Between Ring fingers
    cd00162
    Location:2091 → 2141
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl02148
    Location:1159 → 1289
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:1585 → 1832
    Cullin; Cullin family
    pfam01485
    Location:2255 → 2290
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366 → 440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl11186
    Location:1884 → 1964
    Cullin_Nedd8; Cullin protein neddylation domain
    cl17238
    Location:2090 → 2141
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_039083510.2 → XP_038939438.1  cullin-9 isoform X3

    Related
    ENSRNOP00000104760.1, ENSRNOT00000164147.1
    Conserved Domains (7) summary
    cd00162
    Location:2091 → 2141
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl02148
    Location:1159 → 1289
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:1585 → 1832
    Cullin; Cullin family
    pfam01485
    Location:2162 → 2213
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366 → 440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl11186
    Location:1884 → 1964
    Cullin_Nedd8; Cullin protein neddylation domain
    cl17238
    Location:2090 → 2141
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_063267094.1 → XP_063123164.1  cullin-9 isoform X4

  5. XM_039083512.2 → XP_038939440.1  cullin-9 isoform X6

    Conserved Domains (5) summary
    cl02148
    Location:1159 → 1289
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:1585 → 1832
    Cullin; Cullin family
    pfam11515
    Location:366 → 440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl11186
    Location:1884 → 1964
    Cullin_Nedd8; Cullin protein neddylation domain
    cl17238
    Location:2090 → 2115
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. XM_039083511.2 → XP_038939439.1  cullin-9 isoform X5

    Conserved Domains (8) summary
    smart00647
    Location:1945 → 2007
    IBR; In Between Ring fingers
    cd00162
    Location:1874 → 1924
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl02148
    Location:942 → 1072
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:1368 → 1615
    Cullin; Cullin family
    pfam01485
    Location:2038 → 2073
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:149 → 223
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl11186
    Location:1667 → 1747
    Cullin_Nedd8; Cullin protein neddylation domain
    cl17238
    Location:1873 → 1924
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_005488890.2 RNA Sequence

  2. XR_005488889.2 RNA Sequence

  3. XR_010054591.1 RNA Sequence

  4. XR_005488891.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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