iav inactive [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: iavprovided by FlyBase
Official Full Name: inactiveprovided by FlyBase
Primary source: FLYBASE:FBgn0086693
Locus tag: Dmel_CG4536
See related: AllianceGenome:FB:FBgn0086693
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4536; CT14708; Dmel\CG4536; DmIav; hypoB; Iav; IAV; osm-9; TRPV
Summary: Enables mechanosensitive monoatomic cation channel activity. Contributes to calcium channel activity. Involved in several processes, including adult walking behavior; detection of mechanical stimulus involved in sensory perception of sound; and negative gravitaxis. Part of calcium channel complex. Is active in plasma membrane. Is expressed in several structures, including adult brain; adult chordotonal organ; adult ventral nerve cord; chordotonal neurons; and scolopidial cilium. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV5 (transient receptor potential cation channel subfamily V member 5) and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 6D3-6D3; 1-18 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6813978..6818156)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6708011..6712189)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila.
Title: Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila.
our findings indicate that Iav acts as a key regulator of synaptic development and function by influencing presynaptic resting [Ca(2+)].
Title: A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.
The transient receptor potential channels NOMPC, NANCHUNG, and INACTIVE, but not the dmPIEZO channel, are implicated in mechanotransduction and/or signal amplification for the detection of sound by the larval Cho neurons.
Title: Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
the decision to select the preferred over slightly cooler temperatures requires iav
Title: Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons.
The inactive (iav) protein, a vanilloid receptor subfamily (TRPV) channel subunit, forms a hypotonically activated channel. It is specifically expressed in the chordotonal neurons, localized to their cilia and required for hearing. [iav protein]
Title: Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to calcium channel activity	IPI Inferred from Physical Interaction more info	PubMed
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mechanosensitive monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to cocaine	NAS Non-traceable Author Statement more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of sound	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular process controlling posture	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auditory stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of cation channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inactive

Names: CG4536-PA; iav-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6813978..6818156

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132125.2 → NP_572353.1 inactive [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572353.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3W0

Related

FBpp0070930

Conserved Domains (5) summary

COG0666
Location:127 → 202

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:173 → 315

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:501 → 665

Ion_trans; Ion transport protein

pfam12796
Location:235 → 324

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:173 → 203

ANK; ANK repeat [structural motif]