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Rbm6 RNA binding motif protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315997, updated on 27-Nov-2024

Summary

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Official Symbol
Rbm6provided by RGD
Official Full Name
RNA binding motif protein 6provided by RGD
Primary source
RGD:1560367
See related
EnsemblRapid:ENSRNOG00000018333 AllianceGenome:RGD:1560367
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560367
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human RBM6 (RNA binding motif protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 174.4), Adrenal (RPKM 144.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm6 in Genome Data Viewer
Location:
8q32
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117327607..117431397, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108452687..108552783, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116535403..116635851, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480231 Neighboring gene G protein subunit alpha transducin 1 Neighboring gene semaphorin 3F Neighboring gene RNA binding motif protein 5 Neighboring gene cofilin 1 like 1 Neighboring gene enolase 1, pseudogene 23 Neighboring gene PCNA-associated factor-like Neighboring gene transfer RNA proline (anticodon AGG) 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
  2. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108186.1 → NP_001101656.1  RNA-binding protein 6

    See identical proteins and their annotated locations for NP_001101656.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A0A8I6A326, A6I311, D4ACW0
    Related
    ENSRNOP00000024939.5, ENSRNOT00000024939.7
    Conserved Domains (6) summary
    COG1357
    Location:92 → 251
    YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
    cd12314
    Location:456 → 533
    RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
    cd12563
    Location:651 → 737
    RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
    pfam01585
    Location:1048 → 1091
    G-patch; G-patch domain
    cd16074
    Location:769 → 776
    OCRE; OCRE repeat 1 [structural motif]
    cl23757
    Location:763 → 818
    OCRE; OCRE domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117327607..117431397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081594.2 → XP_038937522.1  RNA-binding protein 6 isoform X3

    Conserved Domains (4) summary
    cd16074
    Location:247 → 254
    OCRE; OCRE repeat 1 [structural motif]
    cl23757
    Location:241 → 296
    OCRE; OCRE domain
    pfam01585
    Location:526 → 569
    G-patch; G-patch domain
    cd12563
    Location:129 → 215
    RRM2_RBM6; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 6 (RBM6)

  2. XM_006243780.5 → XP_006243842.1  RNA-binding protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006243842.1

    UniProtKB/TrEMBL
    A0A8I6A326, A6I311, D4ACW0
    Conserved Domains (6) summary
    COG1357
    Location:92 → 251
    YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
    cd12314
    Location:456 → 533
    RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
    cd12563
    Location:651 → 737
    RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
    pfam01585
    Location:1048 → 1091
    G-patch; G-patch domain
    cd16074
    Location:769 → 776
    OCRE; OCRE repeat 1 [structural motif]
    cl23757
    Location:763 → 818
    OCRE; OCRE domain

  3. XM_063265629.1 → XP_063121699.1  RNA-binding protein 6 isoform X2

  4. XM_063265628.1 → XP_063121698.1  RNA-binding protein 6 isoform X2

  5. XM_006243781.4 → XP_006243843.1  RNA-binding protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006243843.1

    UniProtKB/TrEMBL
    A0A8I6A326, A6I311, D4ACW0
    Conserved Domains (6) summary
    COG1357
    Location:92 → 251
    YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
    cd12314
    Location:456 → 533
    RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
    cd12563
    Location:651 → 737
    RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
    pfam01585
    Location:1048 → 1091
    G-patch; G-patch domain
    cd16074
    Location:769 → 776
    OCRE; OCRE repeat 1 [structural motif]
    cl23757
    Location:763 → 818
    OCRE; OCRE domain

  6. XM_039081595.2 → XP_038937523.1  RNA-binding protein 6 isoform X3

    Conserved Domains (4) summary
    cd16074
    Location:247 → 254
    OCRE; OCRE repeat 1 [structural motif]
    cl23757
    Location:241 → 296
    OCRE; OCRE domain
    pfam01585
    Location:526 → 569
    G-patch; G-patch domain
    cd12563
    Location:129 → 215
    RRM2_RBM6; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 6 (RBM6)

  7. XM_008766535.4 → XP_008764757.1  RNA-binding protein 6 isoform X3

    Conserved Domains (4) summary
    cd16074
    Location:247 → 254
    OCRE; OCRE repeat 1 [structural motif]
    cl23757
    Location:241 → 296
    OCRE; OCRE domain
    pfam01585
    Location:526 → 569
    G-patch; G-patch domain
    cd12563
    Location:129 → 215
    RRM2_RBM6; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 6 (RBM6)
Nucleotide Protein Strain
Heading Accession and Version

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