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Msl2 MSL complex subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315959, updated on 27-Nov-2024

Summary

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Symbol
Msl2provided by RGD
Full Name
MSL complex subunit 2provided by RGD
Primary source
RGD:1310355
See related
EnsemblRapid:ENSRNOG00000023021 AllianceGenome:RGD:1310355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Msl2l1; RGD1310355
Summary
Predicted to enable histone H2B ubiquitin ligase activity and promoter-enhancer loop anchoring activity. Predicted to be involved in DNA damage response; protein monoubiquitination; and regulation of gene expression. Predicted to be part of MSL complex. Predicted to be active in chromatin and nucleus. Orthologous to human MSL2 (MSL complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 172.1), Spleen (RPKM 150.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Msl2 in Genome Data Viewer
Location:
8q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (110555579..110642096)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (101676605..101702818)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (109456097..109480143)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19, pseudogene 8 Neighboring gene propionyl-CoA carboxylase subunit beta Neighboring gene protein phosphatase 2, regulatory subunit B'', alpha Neighboring gene uncharacterized LOC134480092 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2B ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-enhancer loop anchoring activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MSL complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MSL2
Names
male-specific lethal 2 homolog
male-specific lethal 2-like 1
NP_001388814.1
XP_038938512.1
XP_038938513.1
XP_063121668.1
XP_063121669.1
XP_063121670.1
XP_063121671.1
XP_063121672.1
XP_063121673.1
XP_063121674.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401885.1 → NP_001388814.1  E3 ubiquitin-protein ligase MSL2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I2G4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    110555579..110642096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082584.2 → XP_038938512.1  E3 ubiquitin-protein ligase MSL2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AT15
    Conserved Domains (3) summary
    TIGR03551
    Location:203 → 245
    F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
    pfam16682
    Location:414 → 468
    MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
    pfam16685
    Location:3 → 70
    zf-RING_10; zinc RING finger of MSL2

  2. XM_063265600.1 → XP_063121670.1  E3 ubiquitin-protein ligase MSL2 isoform X1

  3. XM_063265601.1 → XP_063121671.1  E3 ubiquitin-protein ligase MSL2 isoform X1

  4. XM_063265603.1 → XP_063121673.1  E3 ubiquitin-protein ligase MSL2 isoform X1

  5. XM_063265604.1 → XP_063121674.1  E3 ubiquitin-protein ligase MSL2 isoform X1

  6. XM_063265598.1 → XP_063121668.1  E3 ubiquitin-protein ligase MSL2 isoform X1

  7. XM_063265599.1 → XP_063121669.1  E3 ubiquitin-protein ligase MSL2 isoform X1

  8. XM_063265602.1 → XP_063121672.1  E3 ubiquitin-protein ligase MSL2 isoform X1

  9. XM_039082585.2 → XP_038938513.1  E3 ubiquitin-protein ligase MSL2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AT15
    Related
    ENSRNOP00000097482.1, ENSRNOT00000108984.2
    Conserved Domains (3) summary
    TIGR03551
    Location:170 → 212
    F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
    pfam16682
    Location:381 → 435
    MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
    cl17238
    Location:1 → 37
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version

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