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Zbtb38 zinc finger and BTB domain containing 38 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315936, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb38provided by RGD
Official Full Name
zinc finger and BTB domain containing 38provided by RGD
Primary source
RGD:1310136
See related
EnsemblRapid:ENSRNOG00000012386 AllianceGenome:RGD:1310136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310136
Summary
Enables DNA-binding transcription factor activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human ZBTB38 (zinc finger and BTB domain containing 38). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 63.6), Heart (RPKM 62.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb38 in Genome Data Viewer
Location:
8q31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (106124181..106231215, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (97284617..97288518, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104566999..104694890, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 78 Neighboring gene uncharacterized LOC120094237 Neighboring gene RAS p21 protein activator 2 Neighboring gene peptidyl-prolyl cis-trans isomerase D pseudogene Neighboring gene uncharacterized LOC100909637 Neighboring gene uncharacterized LOC134480088 Neighboring gene 2-phosphoxylose phosphatase 1 Neighboring gene uncharacterized LOC120094379

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons. Kiefer H, et al. Mol Cell Biol, 2005 Mar. PMID 15713629, Free PMC Article
  2. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Miotto B, et al. Cell Rep, 2014 Apr 24. PMID 24726359
  3. A family of human zinc finger proteins that bind methylated DNA and repress transcription. Filion GJ, et al. Mol Cell Biol, 2006 Jan. PMID 16354688, Free PMC Article
  4. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA, et al. Epigenetics, 2013 Feb. PMID 23324617, Free PMC Article
  5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZENON is involved in the maintenance of panneuronal features and/or in the survival of mature neurons.
    Title: ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyl-CpG binding IEA
Inferred from Electronic Annotation
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 38
Names
zenon
zinc finger protein expressed in neurons
zinc finger transcription factor Kaiso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012471.2 → NP_001012489.2  zinc finger and BTB domain-containing protein 38

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I286, M0RCM7
    Conserved Domains (5) summary
    sd00017
    Location:1019 → 1039
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:15 → 128
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1045 → 1067
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1032 → 1055
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:308 → 401
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    106124181..106231215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265581.1 → XP_063121651.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7
    Related
    ENSRNOP00000103824.1, ENSRNOT00000121360.1

  2. XM_063265579.1 → XP_063121649.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7
    Related
    ENSRNOP00000095257.1, ENSRNOT00000102946.3

  3. XM_063265578.1 → XP_063121648.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7
    Related
    ENSRNOP00000081285.1, ENSRNOT00000111528.2

  4. XM_063265582.1 → XP_063121652.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7
    Related
    ENSRNOP00000067350.1, ENSRNOT00000016625.8

  5. XM_063265575.1 → XP_063121645.1  zinc finger and BTB domain-containing protein 38 isoform X1

  6. XM_063265584.1 → XP_063121654.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7
    Related
    ENSRNOP00000108939.1, ENSRNOT00000154527.1

  7. XM_063265583.1 → XP_063121653.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7

  8. XM_063265576.1 → XP_063121646.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7
    Related
    ENSRNOP00000098232.1, ENSRNOT00000120592.2

  9. XM_063265577.1 → XP_063121647.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7

  10. XM_063265580.1 → XP_063121650.1  zinc finger and BTB domain-containing protein 38 isoform X2

    UniProtKB/TrEMBL
    M0RCM7

RNA

  1. XR_010053975.1 RNA Sequence

  2. XR_010053976.1 RNA Sequence

  3. XR_010053974.1 RNA Sequence

  4. XR_010053973.1 RNA Sequence

  5. XR_010053978.1 RNA Sequence

  6. XR_010053977.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5EXX3.1 GenPept UniProtKB/Swiss-Prot:Q5EXX3

Gene LinkOut

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