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U2surp U2 snRNP-associated SURP domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 315903, updated on 4-Jan-2025

Summary

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Official Symbol
U2surpprovided by RGD
Official Full Name
U2 snRNP-associated SURP domain containingprovided by RGD
Primary source
RGD:1307882
See related
EnsemblRapid:ENSRNOG00000008607 AllianceGenome:RGD:1307882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307882
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Predicted to be located in nucleoplasm. Predicted to be part of U2 snRNP. Predicted to be active in nucleus. Orthologous to human U2SURP (U2 snRNP associated SURP domain containing). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 181.1), Brain (RPKM 171.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See U2surp in Genome Data Viewer
Location:
8q31
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (104898580..104963642, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96018932..96075795, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (103242095..103299082, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 2 Neighboring gene Fcf1 rRNA-processing protein, pseudogene 1 Neighboring gene uncharacterized LOC120094231 Neighboring gene progestin and adipoQ receptor family member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Gilmore-Hebert M, et al. Mol Cancer Res, 2010 Oct. PMID 20858735, Free PMC Article
  2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2 snRNP IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U2 snRNP-associated SURP domain containing; U2 snRNP-associated SURP motif-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430540.1 → NP_001417469.1  U2 snRNP-associated SURP domain containing isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZXP5

  2. NM_001430541.1 → NP_001417470.1  U2 snRNP-associated SURP domain containing isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I255

  3. NM_001430542.1 → NP_001417471.1  U2 snRNP-associated SURP domain containing isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZXP5, D4A4B4

  4. NM_001430543.1 → NP_001417472.1  U2 snRNP-associated SURP domain containing isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I255

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    104898580..104963642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243554.3 → XP_006243616.1  U2 snRNP-associated SURP motif-containing protein isoform X2

    Conserved Domains (4) summary
    smart00582
    Location:540 → 675
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    cd12223
    Location:272 → 355
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:429 → 479
    Surp; Surp module
    pfam08312
    Location:842 → 883
    cwf21; cwf21 domain

  2. XM_039082560.2 → XP_038938488.1  U2 snRNP-associated SURP motif-containing protein isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZXP5
    Conserved Domains (5) summary
    smart00582
    Location:541 → 676
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156 → 352
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam01805
    Location:429 → 480
    Surp; Surp module
    cd12223
    Location:273 → 356
    RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
    cd21370
    Location:836 → 884
    cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

  3. XM_039082559.2 → XP_038938487.1  U2 snRNP-associated SURP motif-containing protein isoform X4

    Conserved Domains (5) summary
    smart00582
    Location:496 → 631
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:112 → 307
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam01805
    Location:384 → 435
    Surp; Surp module
    cd12223
    Location:228 → 311
    RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
    cd21370
    Location:791 → 839
    cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

  4. XM_002729954.7 → XP_002730000.1  U2 snRNP-associated SURP motif-containing protein isoform X3

    Related
    ENSRNOP00000011609.6, ENSRNOT00000011609.9
    Conserved Domains (4) summary
    smart00582
    Location:497 → 632
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    cd12223
    Location:229 → 312
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:386 → 436
    Surp; Surp module
    pfam08312
    Location:799 → 840
    cwf21; cwf21 domain

  5. XM_236501.10 → XP_236501.3  U2 snRNP-associated SURP motif-containing protein isoform X1

    Related
    ENSRNOP00000083935.1, ENSRNOT00000116411.2
    Conserved Domains (4) summary
    smart00582
    Location:541 → 676
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    cd12223
    Location:273 → 356
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:430 → 480
    Surp; Surp module
    pfam08312
    Location:843 → 884
    cwf21; cwf21 domain

  6. XM_017596120.3 → XP_017451609.1  U2 snRNP-associated SURP motif-containing protein isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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