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Agxt Alanine-glyoxylate aminotransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31587, updated on 9-Dec-2024

Summary

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Official Symbol
Agxtprovided by FlyBase
Official Full Name
Alanine-glyoxylate aminotransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0014031
Locus tag
Dmel_CG3926
See related
AllianceGenome:FB:FBgn0014031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AGXT; CG3926; dAgxt; dAGXT; Dm-Spat; Dmel\CG3926; spa; spat; Spat
Summary
Enables alanine-glyoxylate transaminase activity. Involved in glyoxylate catabolic process. Predicted to be active in peroxisome. Is expressed in adult head. Used to study primary hyperoxaluria type 1. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Agxt in Genome Data Viewer
Location:
6B1-6B1; 1-17 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6528948..6530726)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6422981..6424759)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Phenylalanine-GAA 1-1 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L7A Neighboring gene deltex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase. Han Q, et al. FEBS Lett, 2002 Sep 11. PMID 12220660, Free PMC Article
  2. Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster. Yang H, et al. BMC Nephrol, 2018 Jul 6. PMID 29980178, Free PMC Article
  3. The genomic organization of the region containing the Drosophila melanogaster rpL7a (Surf-3) gene differs from those of the mammalian and avian Surfeit loci. Armes N, et al. Mol Cell Biol, 1995 May. PMID 7739520, Free PMC Article
  4. Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting. Wittkopp PJ, et al. Genetics, 2006 Jul. PMID 16702434, Free PMC Article
  5. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-serine-pyruvate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-glyoxylate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-glyoxylate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycine biosynthetic process, by transamination of glyoxylate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glyoxylate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Alanine-glyoxylate aminotransferase
Names
Agxt-PA
CG3926-PA
serine pyruvate aminotransferase
NP_511062.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6528948..6530726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078507.2 → NP_511062.1  Alanine-glyoxylate aminotransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511062.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP18, Q8T0J1, Q9W3Z3
    Related
    FBpp0070875, FBtr0070913
    Conserved Domains (1) summary
    cd06451
    Location:19 → 381
    AGAT_like; Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24510 Q24510
Q9W3Z3.1 Q9W3Z3

Gene LinkOut

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