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Zfp280d zinc finger protein 280D [ Rattus norvegicus (Norway rat) ]

Gene ID: 315798, updated on 4-Jan-2025

Summary

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Official Symbol
Zfp280dprovided by RGD
Official Full Name
zinc finger protein 280Dprovided by RGD
Primary source
RGD:1560796
See related
EnsemblRapid:ENSRNOG00000055631 AllianceGenome:RGD:1560796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Suhw4; RGD1560796
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF280D (zinc finger protein 280D). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 475.5), Brain (RPKM 145.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp280d in Genome Data Viewer
Location:
8q24
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81872108..81961194)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72992655..73080482)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (78858561..78949447)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479978 Neighboring gene uncharacterized LOC108351742 Neighboring gene uncharacterized LOC102546620 Neighboring gene ribosomal protein L35, pseudogene 6 Neighboring gene meiosis-specific nuclear structural 1 Neighboring gene testis expressed 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 280D
Names
suppressor of hairy wing homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108165.2 → NP_001101635.2  zinc finger protein 280D

    See identical proteins and their annotated locations for NP_001101635.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2JU78, A6KEP7, F1M0V0
    Conserved Domains (3) summary
    sd00017
    Location:360 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:323 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45 → 229
    DUF4195; Domain of unknown function (DUF4195)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    81872108..81961194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595664.3 → XP_017451153.1  zinc finger protein 280D isoform X1

    UniProtKB/TrEMBL
    A0A0G2JU78, A6KEP7, F1M0V0
    Related
    ENSRNOP00000068997.1, ENSRNOT00000090047.3
    Conserved Domains (3) summary
    sd00017
    Location:360 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:323 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45 → 229
    DUF4195; Domain of unknown function (DUF4195)

  2. XM_063265541.1 → XP_063121611.1  zinc finger protein 280D isoform X3

    UniProtKB/TrEMBL
    A0A8I6ACS8, A6KEQ0

  3. XM_039081514.2 → XP_038937442.1  zinc finger protein 280D isoform X8

    UniProtKB/TrEMBL
    A0A8I6ACS8
    Conserved Domains (2) summary
    sd00017
    Location:360 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45 → 228
    DUF4195; Domain of unknown function (DUF4195)

  4. XM_063265544.1 → XP_063121614.1  zinc finger protein 280D isoform X9

    UniProtKB/TrEMBL
    A0A8I6ACS8

  5. XM_008766290.4 → XP_008764512.1  zinc finger protein 280D isoform X6

    UniProtKB/TrEMBL
    A0A8I6ACS8
    Conserved Domains (2) summary
    sd00017
    Location:360 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45 → 229
    DUF4195; Domain of unknown function (DUF4195)

  6. XM_008766289.3 → XP_008764511.1  zinc finger protein 280D isoform X4

    UniProtKB/TrEMBL
    A0A8I6ACS8
    Related
    ENSRNOP00000089893.1, ENSRNOT00000095837.2
    Conserved Domains (2) summary
    sd00017
    Location:360 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45 → 229
    DUF4195; Domain of unknown function (DUF4195)

  7. XM_063265546.1 → XP_063121616.1  zinc finger protein 280D isoform X10

  8. XM_039081513.2 → XP_038937441.1  zinc finger protein 280D isoform X2

    UniProtKB/TrEMBL
    F1M0V0
    Related
    ENSRNOP00000108307.1, ENSRNOT00000133119.1
    Conserved Domains (3) summary
    sd00017
    Location:347 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:310 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32 → 215
    DUF4195; Domain of unknown function (DUF4195)

  9. XM_006243357.5 → XP_006243419.1  zinc finger protein 280D isoform X2

    See identical proteins and their annotated locations for XP_006243419.1

    UniProtKB/TrEMBL
    F1M0V0
    Conserved Domains (3) summary
    sd00017
    Location:347 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:310 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32 → 215
    DUF4195; Domain of unknown function (DUF4195)

  10. XM_063265542.1 → XP_063121612.1  zinc finger protein 280D isoform X5

    UniProtKB/TrEMBL
    A0A8I6ACS8

  11. XM_017595665.3 → XP_017451154.1  zinc finger protein 280D isoform X2

    UniProtKB/TrEMBL
    F1M0V0
    Related
    ENSRNOP00000068646.3, ENSRNOT00000089335.3
    Conserved Domains (3) summary
    sd00017
    Location:347 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:310 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32 → 215
    DUF4195; Domain of unknown function (DUF4195)

  12. XM_017595666.3 → XP_017451155.1  zinc finger protein 280D isoform X2

    UniProtKB/TrEMBL
    F1M0V0
    Conserved Domains (3) summary
    sd00017
    Location:347 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:310 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32 → 215
    DUF4195; Domain of unknown function (DUF4195)

  13. XM_039081512.2 → XP_038937440.1  zinc finger protein 280D isoform X2

    UniProtKB/TrEMBL
    F1M0V0
    Conserved Domains (3) summary
    sd00017
    Location:347 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:310 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32 → 215
    DUF4195; Domain of unknown function (DUF4195)

  14. XM_063265543.1 → XP_063121613.1  zinc finger protein 280D isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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