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kdn knockdown [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31579, updated on 9-Dec-2024

Summary

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Official Symbol
kdnprovided by FlyBase
Official Full Name
knockdownprovided by FlyBase
Primary source
FLYBASE:FBgn0261955
Locus tag
Dmel_CG3861
See related
AllianceGenome:FB:FBgn0261955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GM01832; CG 3861; CG3861; CS; csyn; Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033; l(1)G0159
Summary
Enables citrate (Si)-synthase activity. Predicted to be involved in carbohydrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; anal pad primordium; embryonic/larval midgut primordium; and ganglia. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See kdn in Genome Data Viewer
Location:
5F2-5F4; 1-16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6350629..6361323)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6244662..6255356)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B16.6 subunit Neighboring gene swallow pseudogene Neighboring gene swallow

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. Rao RP, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592126, Free PMC Article
  2. Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Schwarze SR, et al. Free Radic Biol Med, 1998 Oct. PMID 9801075
  3. Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster. Simard C, et al. Metabolites, 2020 Sep 6. PMID 32899962, Free PMC Article
  4. A Colorimetric Assay of Citrate Synthase Activity in Drosophila Melanogaster. Wei P, et al. J Vis Exp, 2020 Jan 16. PMID 32009637
  5. Technical knockout, a Drosophila model of mitochondrial deafness. Toivonen JM, et al. Genetics, 2001 Sep. PMID 11560901, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
enables citrate (Si)-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables citrate (Si)-synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables citrate (Si)-synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables citrate (Si)-synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in citrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
knockdown
Names
CG3861-PA
CG3861-PB
citrate synthase
kdn-PA
kdn-PB
lethal (1) G0030
NP_572319.2
NP_727091.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6350629..6361323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167072.2 → NP_727091.1  knockdown, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727091.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP50
    Related
    FBpp0070871
    Conserved Domains (2) summary
    cd06105
    Location:92 → 519
    ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
    PLN02456
    Location:89 → 513
    PLN02456; citrate synthase

  2. NM_132091.3 → NP_572319.2  knockdown, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572319.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T477, Q9W401
    UniProtKB/TrEMBL
    C6TP50
    Related
    FBpp0070872
    Conserved Domains (2) summary
    cd06105
    Location:34 → 461
    ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
    PLN02456
    Location:7 → 455
    PLN02456; citrate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T9J9 Q8T9J9
Q9W401.1 Q9W401

Gene LinkOut

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