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mldr mulder [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31568, updated on 4-Jan-2025

Summary

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Official Symbol
mldrprovided by FlyBase
Official Full Name
mulderprovided by FlyBase
Primary source
FLYBASE:FBgn0029858
Locus tag
Dmel_CG15896
See related
AllianceGenome:FB:FBgn0029858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15896; Dmel\CG15896; MRPP3; PRORP
Summary
Predicted to enable ribonuclease P activity. Involved in mitochondrial tRNA processing. Located in mitochondrion. Part of mitochondrial ribonuclease P complex. Is expressed in organism. Used to study combined oxidative phosphorylation deficiency 54. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mldr in Genome Data Viewer
Location:
5E5-5E6; 1-16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6291303..6294177)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6185336..6188210)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Topoisomerase 3beta Neighboring gene wuho Neighboring gene Regulatory particle triple-A ATPase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduction of Drosophila Mitochondrial RNase P in Skeletal and Heart Muscle Causes Muscle Degeneration, Cardiomyopathy, and Heart Arrhythmia. Saoji M, et al. Front Cell Dev Biol, 2022. PMID 35663400, Free PMC Article
  2. Loss of Individual Mitochondrial Ribonuclease P Complex Proteins Differentially Affects Mitochondrial tRNA Processing In Vivo. Saoji M, et al. Int J Mol Sci, 2021 Jun 4. PMID 34199774, Free PMC Article
  3. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Shafik AM, et al. Hum Mol Genet, 2022 May 19. PMID 34897434, Free PMC Article
  4. Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila. Sen A, et al. Nucleic Acids Res, 2016 Jul 27. PMID 27131785, Free PMC Article
  5. A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. Graves HK, et al. G3 (Bethesda), 2020 Jan 7. PMID 31767637, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA 5'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mulder
Names
CG15896-PA
CG15896-PB
mldr-PA
mldr-PB
NP_001245549.1
NP_572309.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6291303..6294177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258620.2 → NP_001245549.1  mulder, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245549.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5U1E0, Q8SYK6, Q9W413
    Conserved Domains (1) summary
    pfam16953
    Location:288 → 525
    PRORP; Protein-only RNase P

  2. NM_132081.4 → NP_572309.2  mulder, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572309.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5U1E0, Q8SYK6, Q9W413
    Related
    FBpp0070863
    Conserved Domains (1) summary
    pfam16953
    Location:288 → 525
    PRORP; Protein-only RNase P
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U1E0 Q5U1E0
Q8SYK6 Q8SYK6
Q9W413 Q9W413
Q9W413.1

Gene LinkOut

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