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Pou2af3 POU class 2 homeobox associating factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315652, updated on 27-Nov-2024

Summary

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Official Symbol
Pou2af3provided by RGD
Official Full Name
POU class 2 homeobox associating factor 3provided by RGD
Primary source
RGD:1563866
See related
EnsemblRapid:ENSRNOG00000042165 AllianceGenome:RGD:1563866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Colca2; RGD1563866
Summary
Predicted to enable DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Orthologous to human POU2AF3 (POU class 2 homeobox associating factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 12.6), Lung (RPKM 11.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pou2af3 in Genome Data Viewer
Location:
8q23
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60484596..60493475, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51588237..51597114, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55674561..55682811, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RGD1562811 Neighboring gene POU class 2 homeobox associating factor 1 Neighboring gene uncharacterized LOC103693092 Neighboring gene POU class 2 homeobox associating factor 2 Neighboring gene uncharacterized LOC120094149

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Peltekova VD, et al. Int J Cancer, 2014 May 15. PMID 24154973, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables POU domain binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
POU class 2 homeobox associating factor 3
Names
colorectal cancer associated 2
colorectal cancer-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399310.1 → NP_001386239.1  POU class 2 homeobox associating factor 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    Related
    ENSRNOP00000102785.1, ENSRNOT00000148053.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    60484596..60493475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082367.2 → XP_038938295.1  POU class 2 homeobox associating factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G7E3

  2. XM_017596029.3 → XP_017451518.1  POU class 2 homeobox associating factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G7E3, D4A677
    Related
    ENSRNOP00000061856.4, ENSRNOT00000065744.5

  3. XM_039082365.2 → XP_038938293.1  POU class 2 homeobox associating factor 3 isoform X2

    UniProtKB/TrEMBL
    A6J4H3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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