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Bco2 beta-carotene oxygenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315644, updated on 9-Dec-2024

Summary

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Official Symbol
Bco2provided by RGD
Official Full Name
beta-carotene oxygenase 2provided by RGD
Primary source
RGD:1309022
See related
EnsemblRapid:ENSRNOG00000038746 AllianceGenome:RGD:1309022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bcdo2; Ab2-079
Summary
Predicted to enable beta,beta-carotene-9',10'-cleaving oxygenase activity; beta-carotene 15,15'-dioxygenase activity; and carotenoid dioxygenase activity. Predicted to be involved in isoprenoid metabolic process; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species metabolic process. Predicted to act upstream of or within xanthophyll metabolic process. Predicted to be located in ribosome. Predicted to be active in mitochondrion. Orthologous to human BCO2 (beta-carotene oxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 141.8), Liver (RPKM 106.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bco2 in Genome Data Viewer
Location:
8q23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59778571..59803597, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (50882174..50907676, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (54965577..54990604, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene placenta expressed transcript 1 Neighboring gene 6-pyruvoyl-tetrahydropterin synthase Neighboring gene interleukin 18 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex subunit D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine. Raghuvanshi S, et al. Arch Biochem Biophys, 2015 Apr 15. PMID 25575786, Free PMC Article
  2. Production of β-apo-10'-carotenal from β-carotene by human β-carotene-9',10'-oxygenase expressed in E. coli. Kim YS, et al. Biotechnol Lett, 2011 Jun. PMID 21302131
  3. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. Amengual J, et al. FASEB J, 2011 Mar. PMID 21106934, Free PMC Article
  4. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. Kiefer C, et al. J Biol Chem, 2001 Apr 27. PMID 11278918
  5. A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption. Widjaja-Adhi MA, et al. Hum Mol Genet, 2015 Jun 1. PMID 25701869, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellular localization of beta-carotene 15,15' oxygenase-1 (BCO1) and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine
    Title: Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta,beta-carotene-9',10'-cleaving oxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-carotene 15,15'-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carotenoid dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carotene catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carotene catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carotene metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carotenoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinal metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in xanthophyll catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within xanthophyll metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carotenoid-cleaving dioxygenase, mitochondrial
Names
beta,beta-carotene 9',10'-oxygenase
beta-carotene 9', 10'-dioxygenase 2
carotenoid 9',10' monooxygenase II
carotenoid 9',10' monoxygenase II
NP_001121184.1
XP_038937374.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127712.1 → NP_001121184.1  carotenoid-cleaving dioxygenase, mitochondrial

    See identical proteins and their annotated locations for NP_001121184.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133725
    UniProtKB/TrEMBL
    A3KN98
    Related
    ENSRNOP00000055965.2, ENSRNOT00000059192.6
    Conserved Domains (1) summary
    pfam03055
    Location:19 → 531
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    59778571..59803597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081446.2 → XP_038937374.1  carotenoid-cleaving dioxygenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A3KN98
    Conserved Domains (1) summary
    pfam03055
    Location:19 → 531
    RPE65; Retinal pigment epithelial membrane protein
Nucleotide Protein Strain
Heading Accession and Version

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