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Josd Josephin domain containing [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31560, updated on 4-Jan-2025

Summary

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Official Symbol
Josdprovided by FlyBase
Official Full Name
Josephin domain containingprovided by FlyBase
Primary source
FLYBASE:FBgn0029853
Locus tag
Dmel_CG3781
See related
AllianceGenome:FB:FBgn0029853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3781; Dmel\CG3781; JosD2; Q9W422
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to several human genes including JOSD1 (Josephin domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Josd in Genome Data Viewer
Location:
5E3-5E3; 1-16 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6261169..6262119)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6155202..6156152)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rabconnectin-3A Neighboring gene schlank Neighboring gene Spliceosomal protein on the X Neighboring gene Spt6 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-5E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Josephin domain (JD) containing proteins are predicted to bind to the same interactors: Implications for spinocerebellar ataxia type 3 (SCA3) studies using Drosophila melanogaster mutants. Sousa E Silva R, et al. Front Mol Neurosci, 2023. PMID 37008788, Free PMC Article
  2. Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease. Alexopoulou Z, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27444016, Free PMC Article
  3. The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Yang CS, et al. Cell Death Differ, 2014 Apr. PMID 24362437, Free PMC Article
  4. Genome-scale analysis of positionally relocated genes. Bhutkar A, et al. Genome Res, 2007 Dec. PMID 17989252, Free PMC Article
  5. The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy. Pai YL, et al. Cell Death Dis, 2023 Aug 22. PMID 37607937, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
josephin domain containing
Names
CG3781-PA
Josd-PA
NP_572303.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6261169..6262119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132075.4 → NP_572303.4  josephin domain containing [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572303.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MTV0, Q9W422
    UniProtKB/TrEMBL
    C4XVM0
    Related
    FBpp0070860
    Conserved Domains (1) summary
    pfam02099
    Location:44 → 184
    Josephin; Josephin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W422.3 Q9W422

Gene LinkOut

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