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C1qtnf5 C1q and TNF related 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315598, updated on 27-Nov-2024

Summary

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Official Symbol
C1qtnf5provided by RGD
Official Full Name
C1q and TNF related 5provided by RGD
Primary source
RGD:1308802
See related
EnsemblRapid:ENSRNOG00000007613 AllianceGenome:RGD:1308802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Adie
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within inner ear development and protein secretion. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and lateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cell projection; extracellular space; and plasma membrane. Human ortholog(s) of this gene implicated in late-onset retinal degeneration. Orthologous to human C1QTNF5 (C1q and TNF related 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 88.1), Uterus (RPKM 84.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See C1qtnf5 in Genome Data Viewer
Location:
8q22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53347754..53349912)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44450934..44453075)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48443515..48445639)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 2 Neighboring gene membrane frizzled-related protein Neighboring gene ring finger protein 26 Neighboring gene uncharacterized LOC120094132

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Yang WM, et al. Biochem Biophys Res Commun, 2014 Sep 26. PMID 25195818
  2. C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. Park SY, et al. J Biol Chem, 2009 Oct 9. PMID 19651784, Free PMC Article
  3. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Mandal MN, et al. Invest Ophthalmol Vis Sci, 2006 Dec. PMID 17122142
  4. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Wong GW, et al. Biochem J, 2008 Dec 1. PMID 18783346, Free PMC Article
  5. Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. Lu CC, et al. J Neurosci, 2011 Jul 27. PMID 21795542, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation.
    Title: CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation.
  2. These results highlight C1QTNF5 as a putative biomarker for mitochondrial dysfunction and a potent activator of AMPK.
    Title: C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109436

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inner ear development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 5
Names
C1q and tumor necrosis factor related protein 5
adiponectin e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012123.1 → NP_001012123.1  complement C1q tumor necrosis factor-related protein 5 precursor

    See identical proteins and their annotated locations for NP_001012123.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089992
    UniProtKB/Swiss-Prot
    Q5FVH0
    UniProtKB/TrEMBL
    A0A3B0ITJ1
    Conserved Domains (2) summary
    pfam01391
    Location:29 → 95
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:105 → 232
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53347754..53349912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081421.2 → XP_038937349.1  complement C1q tumor necrosis factor-related protein 5 isoform X1

    Related
    ENSRNOP00000010127.5, ENSRNOT00000010127.7
    Conserved Domains (2) summary
    pfam00386
    Location:198 → 325
    C1q; C1q domain
    pfam01391
    Location:122 → 188
    Collagen; Collagen triple helix repeat (20 copies)

  2. XM_017595622.3 → XP_017451111.1  complement C1q tumor necrosis factor-related protein 5 isoform X2

    UniProtKB/Swiss-Prot
    Q5FVH0
    UniProtKB/TrEMBL
    A0A3B0ITJ1
    Conserved Domains (2) summary
    pfam01391
    Location:29 → 95
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:105 → 232
    C1q; C1q domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVH0.1 GenPept UniProtKB/Swiss-Prot:Q5FVH0

Gene LinkOut

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