U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dtn detonator [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31555, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
dtnprovided by FlyBase
Official Full Name
detonatorprovided by FlyBase
Primary source
FLYBASE:FBgn0262730
Locus tag
Dmel_CG14446
See related
AllianceGenome:FB:FBgn0262730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14446; CG14446 CES; Dmel\CG14446; lincRNA.S8753; MRE2
Summary
Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to several human genes including TMEM132A (transmembrane protein 132A); TMEM132B (transmembrane protein 132B); and TMEM132C (transmembrane protein 132C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dtn in Genome Data Viewer
Location:
5E1-5E1; 1-16 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6225647..6236218)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6119680..6130251)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ER GDP-fucose transporter Neighboring gene spaghetti squash Neighboring gene uncharacterized protein Neighboring gene Rabconnectin-3A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster. Chon C, et al. PLoS One, 2021. PMID 33444382, Free PMC Article
  2. Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex. Kaye EG, et al. Mol Cell Biol, 2017 Nov 1. PMID 28784719, Free PMC Article
  3. Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators. Li J, et al. Cell, 2020 Jan 23. PMID 31955847, Free PMC Article
  4. Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response. Gupta K, et al. PLoS Genet, 2023 Sep. PMID 37733787, Free PMC Article
  5. Identification and expression analysis of putative mRNA-like non-coding RNA in Drosophila. Inagaki S, et al. Genes Cells, 2005 Dec. PMID 16324153

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster.
    Title: Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
detonator
Names
CG14446-PB
CG14446-PC
CG14446-PD
CG14446-PE
dtn-PB
dtn-PC
dtn-PD
dtn-PE
mRNA-like ncRNA in embryogenesis 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6225647..6236218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258618.2 → NP_001245547.1  detonator, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W427
    Conserved Domains (4) summary
    pfam15705
    Location:18 → 170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:881 → 984
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:440 → 795
    TMEM132; Transmembrane protein family 132
    cl02708
    Location:623 → 676
    Big_2; Bacterial Ig-like domain (group 2)

  2. NM_001298003.1 → NP_001284932.1  detonator, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284932.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JDW6
    Conserved Domains (4) summary
    pfam15705
    Location:18 → 170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:881 → 984
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:440 → 795
    TMEM132; Transmembrane protein family 132
    cl02708
    Location:623 → 676
    Big_2; Bacterial Ig-like domain (group 2)

  3. NM_001298004.1 → NP_001284933.1  detonator, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JEB0
    Conserved Domains (4) summary
    pfam15705
    Location:18 → 170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:881 → 984
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:440 → 795
    TMEM132; Transmembrane protein family 132
    cl02708
    Location:623 → 676
    Big_2; Bacterial Ig-like domain (group 2)

  4. NM_132072.4 → NP_572300.2  detonator, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572300.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W427
    Conserved Domains (4) summary
    pfam15705
    Location:18 → 170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:881 → 984
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:440 → 795
    TMEM132; Transmembrane protein family 132
    cl02708
    Location:623 → 676
    Big_2; Bacterial Ig-like domain (group 2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W427 Q9W427
X2JDW6 X2JDW6
X2JEB0 X2JEB0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous