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Tsp5D Tetraspanin 5D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31540, updated on 4-Jan-2025

Summary

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Official Symbol
Tsp5Dprovided by FlyBase
Official Full Name
Tetraspanin 5Dprovided by FlyBase
Primary source
FLYBASE:FBgn0029837
Locus tag
Dmel_CG4690
See related
AllianceGenome:FB:FBgn0029837
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4690; Dm.Tsp5D; Dmel\CG4690; tsp5D
Summary
Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Tsp5D in Genome Data Viewer
Location:
5D3-5D3; 1-15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6069131..6074857, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5963164..5968890, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Shulman JM, et al. Am J Hum Genet, 2011 Feb 11. PMID 21295279, Free PMC Article
  2. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
  3. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article
  4. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467
  5. Changes in organelle position and epithelial architecture associated with loss of CrebA. Fox RM, et al. Biol Open, 2015 Feb 13. PMID 25681391, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin 5D
Names
CG4690-PA
CG4690-PB
CG4690-PC
Tsp5D-PA
Tsp5D-PB
Tsp5D-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6069131..6074857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078499.5 → NP_511054.4  tetraspanin 5D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511054.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS10, Q9W441
    Conserved Domains (1) summary
    pfam00335
    Location:9 → 252
    Tetraspannin; Tetraspanin family

  2. NM_001144691.2 → NP_001138163.1  tetraspanin 5D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS10, Q9W441
    Conserved Domains (1) summary
    pfam00335
    Location:9 → 252
    Tetraspannin; Tetraspanin family

  3. NM_001272337.1 → NP_001259266.1  tetraspanin 5D, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDV2, Q8MS10
    Conserved Domains (2) summary
    cd03165
    Location:105 → 228
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:8 → 256
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDV2 M9PDV2
Q8MS10 Q8MS10
Q9W441 Q9W441

Gene LinkOut

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