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GAA1 Glycosylphosphatidylinositol anchor attachment 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31517, updated on 4-Jan-2025

Summary

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Official Symbol
GAA1provided by FlyBase
Official Full Name
Glycosylphosphatidylinositol anchor attachment 1provided by FlyBase
Primary source
FLYBASE:FBgn0029818
Locus tag
Dmel_CG3033
See related
AllianceGenome:FB:FBgn0029818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3033; Dmel\CG3033; GPAA1
Summary
Involved in GPI anchor biosynthetic process and rhabdomere membrane biogenesis. Located in endomembrane system. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to human GPAA1 (glycosylphosphatidylinositol anchor attachment 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See GAA1 in Genome Data Viewer
Location:
5C5-5C5; 1-14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5870841..5873357, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5764874..5767390, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene males absent on the first Neighboring gene Ubiquitin specific protease 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
  2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
  3. Enhanced nucleotide chemistry and toehold nanotechnology reveals lncRNA spreading on chromatin. Machyna M, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32157249
  4. Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes. Kind J, et al. Genes Dev, 2007 Aug 15. PMID 17699750, Free PMC Article
  5. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhabdomere membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glycosylphosphatidylinositol anchor attachment 1
Names
CG3033-PA
GAA1-PA
glycosylphosphatidylinositol anchor attachment 1 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5870841..5873357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132045.4 → NP_572273.2  glycosylphosphatidylinositol anchor attachment 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572273.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8B2, Q9W464
    Related
    FBpp0070795
    Conserved Domains (1) summary
    pfam04114
    Location:127 → 639
    Gaa1; Gaa1-like, GPI transamidase component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961V1 Q961V1
Q9W464 Q9W464

Gene LinkOut

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