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Jrk Jrk helix-turn-helix protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 315073, updated on 27-Nov-2024

Summary

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Official Symbol
Jrkprovided by RGD
Official Full Name
Jrk helix-turn-helix proteinprovided by RGD
Primary source
RGD:1306316
See related
EnsemblRapid:ENSRNOG00000027238 AllianceGenome:RGD:1306316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity and mRNA binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human JRK (Jrk helix-turn-helix protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 52.9), Thymus (RPKM 41.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Jrk in Genome Data Viewer
Location:
7q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (108479646..108484329, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (106590662..106595345, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (115941788..115946471, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479925 Neighboring gene U6 spliceosomal RNA Neighboring gene activity-regulated cytoskeleton-associated protein Neighboring gene prostate stem cell antigen Neighboring gene thioesterase superfamily member 6 Neighboring gene secreted Ly6/Plaur domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons. Liu W, et al. J Neurosci, 2002 Jan 1. PMID 11756500, Free PMC Article
  2. Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. Benchabane H, et al. EMBO J, 2011 Apr 20. PMID 21399610, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
NOT located_in ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
jerky protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104612.2 → NP_001098082.1  jerky protein homolog

    See identical proteins and their annotated locations for NP_001098082.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZTF2, A7YY82
    Related
    ENSRNOP00000099750.1, ENSRNOT00000135023.1
    Conserved Domains (3) summary
    smart00674
    Location:83 → 147
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam03184
    Location:213 → 382
    DDE_1; DDE superfamily endonuclease
    pfam04218
    Location:14 → 66
    CENP-B_N; CENP-B N-terminal DNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    108479646..108484329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241728.4 → XP_006241790.1  jerky protein homolog isoform X1

    See identical proteins and their annotated locations for XP_006241790.1

    UniProtKB/TrEMBL
    A0A8I5ZTF2, A7YY82
    Related
    ENSRNOP00000105530.1, ENSRNOT00000157132.1
    Conserved Domains (3) summary
    smart00674
    Location:83 → 147
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam03184
    Location:213 → 382
    DDE_1; DDE superfamily endonuclease
    pfam04218
    Location:14 → 66
    CENP-B_N; CENP-B N-terminal DNA-binding domain
Nucleotide Protein Strain
Heading Accession and Version

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