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Arhgef25 Rho guanine nucleotide exchange factor 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314904, updated on 27-Nov-2024

Summary

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Official Symbol
Arhgef25provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 25provided by RGD
Primary source
RGD:735210
See related
EnsemblRapid:ENSRNOG00000005034 AllianceGenome:RGD:735210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Geft
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Predicted to be located in myofibril. Predicted to be active in cytoplasm and plasma membrane. Predicted to be extrinsic component of membrane. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 89.2), Brain (RPKM 80.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef25 in Genome Data Viewer
Location:
7q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64891260..64898382, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63005938..63013325, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70469304..70476633, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 like 1 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1 Neighboring gene solute carrier family 26, member 10 Neighboring gene uncharacterized LOC134479708 Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RhoA promotes differentiation of WB-F344 cells into the biliary lineage. Yao H, et al. Differentiation, 2009 Feb. PMID 19281775
  2. Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain. Qu MJ, et al. Ann Biomed Eng, 2008 Sep. PMID 18566890
  3. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. Ongherth A, et al. J Mol Cell Cardiol, 2015 Nov. PMID 26392029
  4. Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity. Smith TK, et al. Proc Natl Acad Sci U S A, 2008 Jun 17. PMID 18541910, Free PMC Article
  5. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. Guo X, et al. J Biol Chem, 2003 Apr 11. PMID 12547822

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF.
    Title: p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
  2. cells with ectopically active RhoA expression were found to form bile-duct-like structures even without Matrigel treatment
    Title: RhoA promotes differentiation of WB-F344 cells into the biliary lineage.
  3. the frequency-dependent expression of h1-calponin under cyclic strain is mediated at least partly by the regulation of Rac and Rho-GDI alpha expression on the activation of p38 pathway
    Title: Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72605

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
located_in myofibril ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 25
Names
RAC/CDC42 exchange factor
Rho guanine nucleotide exchange factor (GEF) 25
RhoA/RAC/CDC42 exchange factor
guanine nucleotide exchange factor GEFT
rac/Cdc42/Rho exchange factor GEFT
rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400956.1 → NP_001387885.1  rho guanine nucleotide exchange factor 25

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8L2Q2D0, A6HQT2
    Related
    ENSRNOP00000006800.6, ENSRNOT00000006800.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    64891260..64898382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241455.5 → XP_006241517.1  rho guanine nucleotide exchange factor 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3X0, A0A8I6AFR6
    Conserved Domains (2) summary
    cd13241
    Location:346 → 488
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:171 → 342
    RhoGEF; RhoGEF domain

  2. XM_006241458.5 → XP_006241520.1  rho guanine nucleotide exchange factor 25 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AFR6
    Conserved Domains (2) summary
    cd13241
    Location:369 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:194 → 365
    RhoGEF; RhoGEF domain

  3. XM_039079147.2 → XP_038935075.1  rho guanine nucleotide exchange factor 25 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A2C8
    Conserved Domains (2) summary
    cd13241
    Location:296 → 438
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:121 → 291
    RhoGEF; RhoGEF domain

  4. XM_063263506.1 → XP_063119576.1  rho guanine nucleotide exchange factor 25 isoform X3

    Related
    ENSRNOP00000087274.2, ENSRNOT00000107552.2

  5. XM_006241456.5 → XP_006241518.1  rho guanine nucleotide exchange factor 25 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AL50
    Related
    ENSRNOP00000086978.2, ENSRNOT00000100160.2
    Conserved Domains (2) summary
    cd13241
    Location:339 → 481
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:164 → 335
    RhoGEF; RhoGEF domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199395.1: Suppressed sequence

    Description
    NM_199395.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P720.1 GenPept UniProtKB/Swiss-Prot:Q6P720

Gene LinkOut

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