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Zfc3h1 zinc finger, C3H1-type containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 314836, updated on 27-Nov-2024

Summary

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Symbol
Zfc3h1provided by RGD
Full Name
zinc finger, C3H1-type containingprovided by RGD
Primary source
RGD:1306287
See related
EnsemblRapid:ENSRNOG00000053060 AllianceGenome:RGD:1306287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Psrc2; RGD1306287
Summary
Predicted to be involved in RNA processing. Predicted to be located in nucleus. Predicted to be part of exosome (RNase complex). Orthologous to human ZFC3H1 (zinc finger C3H1-type containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 236.1), Spleen (RPKM 213.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfc3h1 in Genome Data Viewer
Location:
7q22
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (52894417..52950755)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (51008251..51064666)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58365979..58424326)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 19 Neighboring gene THAP domain containing 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 42 Neighboring gene MICOS complex subunit Mic10-like Neighboring gene transfer RNA proline (anticodon AGG) 57 Neighboring gene leucine rich repeat containing G protein coupled receptor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts. Meola N, et al. Mol Cell, 2016 Nov 3. PMID 27871484
  2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger C3H1 domain-containing protein
Names
proline/serine-rich coiled-coil 2
zinc finger C3H1 domain-containing protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432363.1 → NP_001419292.1  zinc finger C3H1 domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6A504

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    52894417..52950755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080126.2 → XP_038936054.1  zinc finger C3H1 domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5R4
    Related
    ENSRNOP00000073527.2, ENSRNOT00000081891.3
    Conserved Domains (4) summary
    COG4235
    Location:1352 → 1457
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    TIGR02168
    Location:739 → 1011
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:1609 → 1635
    TPR; TPR repeat [structural motif]
    pfam10650
    Location:1190 → 1209
    zf-C3H1; Putative zinc-finger domain

  2. XM_039080127.2 → XP_038936055.1  zinc finger C3H1 domain-containing protein isoform X2

    Related
    ENSRNOP00000087884.1, ENSRNOT00000109116.2
    Conserved Domains (4) summary
    COG4235
    Location:1352 → 1457
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    TIGR02168
    Location:739 → 1011
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:1609 → 1635
    TPR; TPR repeat [structural motif]
    pfam10650
    Location:1190 → 1209
    zf-C3H1; Putative zinc-finger domain

  3. XM_063264419.1 → XP_063120489.1  zinc finger C3H1 domain-containing protein isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials