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Washc4 WASH complex subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314690, updated on 27-Nov-2024

Summary

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Official Symbol
Washc4provided by RGD
Official Full Name
WASH complex subunit 4provided by RGD
Primary source
RGD:1309995
See related
EnsemblRapid:ENSRNOG00000008331 AllianceGenome:RGD:1309995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309995
Summary
Predicted to be involved in endosomal transport and endosome organization. Predicted to act upstream of or within several processes, including endolysosomal toll-like receptor signaling pathway; neuromuscular process; and regulation of protein complex stability. Predicted to be located in nucleoplasm. Predicted to be part of BLOC-1 complex and WASH complex. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 43. Orthologous to human WASHC4 (WASH complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 314.2), Spleen (RPKM 278.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Washc4 in Genome Data Viewer
Location:
7q13
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22075546..22127847, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20187905..20240228, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26309279..26361221, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549680 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 Neighboring gene integral membrane protein 2A, pseudogene 1 Neighboring gene aldehyde dehydrogenase 1 family, member L2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα. Ryder PV, et al. Mol Biol Cell, 2013 Jul. PMID 23676666, Free PMC Article
  2. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
  3. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. Harbour ME, et al. J Cell Sci, 2010 Nov 1. PMID 20923837, Free PMC Article
  4. Retromer and sorting nexins in endosomal sorting. Gallon M, et al. Biochem Soc Trans, 2015 Feb. PMID 25619244
  5. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Derivery E, et al. Dev Cell, 2009 Nov. PMID 19922875

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cognition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endolysosomal toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WASH complex subunit 4
Names
WASH complex subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399772.1 → NP_001386701.1  WASH complex subunit 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000011326.7, ENSRNOT00000011326.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    22075546..22127847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241205.5 → XP_006241267.1  WASH complex subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006241267.1

    UniProtKB/TrEMBL
    A6IFG4, D4A7I6
    Conserved Domains (3) summary
    pfam14744
    Location:612 → 945
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:32 → 600
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:966 → 1135
    WASH-7_C; WASH complex subunit 7, C-terminal

  2. XM_008765293.3 → XP_008763515.1  WASH complex subunit 4 isoform X2

    See identical proteins and their annotated locations for XP_008763515.1

    UniProtKB/TrEMBL
    A6IFG5
    Conserved Domains (3) summary
    pfam14744
    Location:424 → 757
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:1 → 412
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:778 → 947
    WASH-7_C; WASH complex subunit 7, C-terminal

  3. XM_039080078.2 → XP_038936006.1  WASH complex subunit 4 isoform X3

    Conserved Domains (3) summary
    pfam14744
    Location:117 → 461
    WASH-7_mid; WASH complex subunit 7
    pfam14745
    Location:1 → 112
    WASH-7_N; WASH complex subunit 7, N-terminal
    pfam14746
    Location:478 → 647
    WASH-7_C; WASH complex subunit 7, C-terminal

RNA

  1. XR_005486803.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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