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Adamts10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314655, updated on 27-Nov-2024

Summary

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Official Symbol
Adamts10provided by RGD
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 10provided by RGD
Primary source
RGD:1598320
See related
EnsemblRapid:ENSRNOG00000008857 AllianceGenome:RGD:1598320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in collagen-containing extracellular matrix and microfibril. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 345.4), Spleen (RPKM 133.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adamts10 in Genome Data Viewer
Location:
7q11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15033859..15063800)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14331659..14361620)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18409147..18439012)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NudC domain containing 2, pseudogene 1 Neighboring gene uncharacterized LOC102549242 Neighboring gene uncharacterized LOC120093540 Neighboring gene myosin IF Neighboring gene BAF nuclear assembly factor 1, pseudogene 1 Neighboring gene zinc finger protein 414

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of ADAMTS10. Wu HJ, et al. Matrix Biol, 2022 Nov. PMID 36216203, Free PMC Article
  2. Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10. Wu HJ, et al. Invest Ophthalmol Vis Sci, 2021 Aug 2. PMID 34424262, Free PMC Article
  3. ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. Kutz WE, et al. J Biol Chem, 2011 May 13. PMID 21402694, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124747

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 10
Names
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271445.1 → NP_001258374.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K229
    Related
    ENSRNOP00000072082.1, ENSRNOT00000086336.3
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1070 → 1102
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    15033859..15063800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079031.2 → XP_038934959.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K229
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1070 → 1102
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_039079032.2 → XP_038934960.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X2

    Conserved Domains (7) summary
    smart00209
    Location:484 → 536
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:173 → 388
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:640 → 752
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:80 → 114
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1004 → 1036
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:403 → 471
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:882 → 936
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_063263434.1 → XP_063119504.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X3

  4. XM_039079033.2 → XP_038934961.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X4

    Conserved Domains (4) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain

  5. XM_017594822.2 → XP_017450311.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X5

    UniProtKB/TrEMBL
    A6KQG5

  6. XM_017594823.2 → XP_017450312.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X6

    UniProtKB/TrEMBL
    A6KQG5

RNA

  1. XR_005486613.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034930.1: Suppressed sequence

    Description
    NM_001034930.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: ADAMTS10 (GeneID:513140).
Nucleotide Protein Strain
Heading Accession and Version

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