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Usp16-45 Ubiquitin specific protease 16/45 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31458, updated on 9-Dec-2024

Summary

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Official Symbol
Usp16-45provided by FlyBase
Official Full Name
Ubiquitin specific protease 16/45provided by FlyBase
Primary source
FLYBASE:FBgn0029763
Locus tag
Dmel_CG4165
See related
AllianceGenome:FB:FBgn0029763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16; Usp45; USP45
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 19. Orthologous to several human genes including USP45 (ubiquitin specific peptidase 45). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Usp16-45 in Genome Data Viewer
Location:
4F10-4F10; 1-11 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5421533..5427219)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5315566..5321252)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nutrient Amino Acid Transporter 1 Neighboring gene spoonbill Neighboring gene long non-coding RNA:CR45517 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. Jacomin AC, et al. PLoS One, 2015. PMID 26571504, Free PMC Article
  2. Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis. Hadad M, et al. Mech Dev, 2011 Sep-Dec. PMID 21983075
  3. RNA-binding protein Roquin negatively regulates STING-dependent innate immune response in Drosophila. Du BB, et al. Yi Chuan, 2020 Dec 17. PMID 33509784
  4. fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Yagi Y, et al. Genes Cells, 2013 Nov. PMID 23919485
  5. The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Li L, et al. Development, 2013 Dec. PMID 24173801, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin specific protease 16/45
Names
CG4165-PA
CG4165-PB
CG4165-PD
CG4165-PE
CG4165-PF
Usp16-45-PA
Usp16-45-PB
Usp16-45-PD
Usp16-45-PE
Usp16-45-PF
NP_001284890.1
NP_572220.1
NP_726993.1
NP_726994.1
NP_726995.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5421533..5427219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167037.2 → NP_726995.1  ubiquitin specific protease 16/45, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726995.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4C3
    Related
    FBpp0070738
    Conserved Domains (3) summary
    cd02667
    Location:849 → 1123
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:307 → 512
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:108 → 159
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. NM_001297961.1 → NP_001284890.1  ubiquitin specific protease 16/45, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284890.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4C3
    Conserved Domains (3) summary
    cd02667
    Location:849 → 1123
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:307 → 512
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:108 → 159
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  3. NM_131992.3 → NP_572220.1  ubiquitin specific protease 16/45, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572220.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4C3
    Related
    FBpp0070739
    Conserved Domains (3) summary
    cd02667
    Location:849 → 1123
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:307 → 512
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:108 → 159
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  4. NM_167035.2 → NP_726993.1  ubiquitin specific protease 16/45, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4C3
    Related
    FBpp0070741
    Conserved Domains (3) summary
    cd02667
    Location:849 → 1123
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:307 → 512
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:108 → 159
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  5. NM_167036.2 → NP_726994.1  ubiquitin specific protease 16/45, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4C3
    Related
    FBpp0309403
    Conserved Domains (3) summary
    cd02667
    Location:849 → 1123
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:307 → 512
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:108 → 159
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W4C3 Q9W4C3
Q9W4C3.1

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