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Cdkl1 cyclin dependent kinase like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314198, updated on 4-Jan-2025

Summary

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Official Symbol
Cdkl1provided by RGD
Official Full Name
cyclin dependent kinase like 1provided by RGD
Primary source
RGD:1305080
See related
EnsemblRapid:ENSRNOG00000038720 AllianceGenome:RGD:1305080
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in heart development. Predicted to be located in ciliary transition zone and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CDKL1 (cyclin dependent kinase like 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 602.0) and Brain (RPKM 34.4) See more
Orthologs
human mouse all
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Genomic context

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See Cdkl1 in Genome Data Viewer
Location:
6q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93960157..94005207, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88224154..88273434, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92076247..92123108, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene distal membrane arm assembly component 2 like Neighboring gene uncharacterized LOC102548655 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene atlastin GTPase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of second messenger- and cyclin-dependent protein kinases during postnatal development of rat heart. Kim SO, et al. J Cell Biochem, 1998 Jun 15. PMID 9620176
  2. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in ciliary transition zone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase-like 1
Names
cyclin-dependent kinase-like 1 (CDC2-related kinase)
NP_001020292.1
XP_006240235.1
XP_038968181.1
XP_038968182.1
XP_038968183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025121.1 → NP_001020292.1  cyclin-dependent kinase-like 1

    See identical proteins and their annotated locations for NP_001020292.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081896
    UniProtKB/Swiss-Prot
    Q66HE7
    UniProtKB/TrEMBL
    A0A8L2UHZ3, A6HBX5
    Related
    ENSRNOP00000006374.7, ENSRNOT00000006374.7
    Conserved Domains (2) summary
    cd07847
    Location:2 → 287
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    pfam00069
    Location:4 → 287
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    93960157..94005207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112254.2 → XP_038968182.1  cyclin-dependent kinase-like 1 isoform X2

    Conserved Domains (1) summary
    cd07847
    Location:2 → 287
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

  2. XM_039112253.2 → XP_038968181.1  cyclin-dependent kinase-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJE5
    Related
    ENSRNOP00000092011.1, ENSRNOT00000103862.2
    Conserved Domains (1) summary
    cd07847
    Location:2 → 287
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

  3. XM_006240173.5 → XP_006240235.1  cyclin-dependent kinase-like 1 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:66 → 232
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039112255.2 → XP_038968183.1  cyclin-dependent kinase-like 1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:2 → 220
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HE7.1 GenPept UniProtKB/Swiss-Prot:Q66HE7

Gene LinkOut

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