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Pdha - Pyruvate dehydrogenase E1 alpha subunit

Predicted to enable pyruvate dehydrogenase (NAD+) activity and pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Used to study disease of metabolism and retinal degeneration. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure 70. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa