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Pcare photoreceptor cilium actin regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 313891, updated on 27-Nov-2024

Summary

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Official Symbol
Pcareprovided by RGD
Official Full Name
photoreceptor cilium actin regulatorprovided by RGD
Primary source
RGD:1304963
See related
EnsemblRapid:ENSRNOG00000008942 AllianceGenome:RGD:1304963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304963
Summary
Predicted to be involved in photoreceptor cell outer segment organization and protein localization to photoreceptor outer segment. Predicted to be located in cone photoreceptor outer segment. Predicted to be active in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in retinitis pigmentosa 54. Orthologous to human PCARE (photoreceptor cilium actin regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 84.3) and Muscle (RPKM 29.1) See more
Orthologs
human mouse all
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Genomic context

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See Pcare in Genome Data Viewer
Location:
6q14
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (29469232..29478541)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (23749700..23758424)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (23337507..23346232)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ALK receptor tyrosine kinase Neighboring gene histidine-rich glycoprotein-like Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene TOG array regulator of axonemal microtubules 2 Neighboring gene small nucleolar RNA, C/D box 53B Neighboring gene WD repeat domain 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Kevany BM, et al. Hum Mol Genet, 2015 May 1. PMID 25616964, Free PMC Article
  2. Discovery and functional analysis of a retinitis pigmentosa gene, C2ORF71. Nishimura DY, et al. Am J Hum Genet, 2010 May 14. PMID 20398886, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in photoreceptor cell outer segment organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within photoreceptor cell outer segment organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cone photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
is_active_in photoreceptor inner segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
photoreceptor cilium actin regulator
Names
uncharacterized protein C2orf71 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399236.1 → NP_001386165.1  photoreceptor cilium actin regulator

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000011832.8, ENSRNOT00000011832.9
    Conserved Domains (1) summary
    pfam15449
    Location:1 → 1246
    Retinal; Retinal protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    29469232..29478541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239771.5 → XP_006239833.1  photoreceptor cilium actin regulator isoform X1

    See identical proteins and their annotated locations for XP_006239833.1

    UniProtKB/TrEMBL
    D3ZS67
    Conserved Domains (1) summary
    pfam15449
    Location:1 → 1247
    Retinal; Retinal protein
Nucleotide Protein Strain
Heading Accession and Version

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