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mei-9 meiotic 9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31373, updated on 9-Dec-2024

Summary

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Official Symbol
mei-9provided by FlyBase
Official Full Name
meiotic 9provided by FlyBase
Primary source
FLYBASE:FBgn0002707
Locus tag
Dmel_CG3697
See related
AllianceGenome:FB:FBgn0002707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3697; DhR1; Dmel\CG3697; DmXPF; Mei-9; MEI-9; mei9; mus(1)110; mus110; Rad1p; xpf/mei-9
Summary
Enables protein heterodimerization activity. Involved in DNA metabolic process; female meiosis chromosome segregation; and oocyte fate determination. Part of protein-containing complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See mei-9 in Genome Data Viewer
Location:
4B6-4B6; 1-7 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4314230..4318801, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4208263..4212834, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44957 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46156 Neighboring gene Nucleolar protein 66 Neighboring gene mitochondrial ribosomal protein L33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of recombination-deficient and repair-deficient loci on meiotic and mitotic chromosome behavior in Drosophila melanogaster. Baker BS, et al. Basic Life Sci, 1980. PMID 6783029
  2. Induced crossing-over in Drosophila melanogaster germ cells of DNA repair-proficient and repair-deficient (mei-9L1) males following larval feeding with 5-azacytidine and mitomycin C. Pontecorvo G, et al. Mutat Res, 1992 Apr. PMID 1373843
  3. Apurinic endonuclease activity from wild-type and repair-deficient mei-9 Drosophila ovaries. Venugopal S, et al. Mol Gen Genet, 1990 May. PMID 1696350
  4. Reduction of spontaneous somatic mutation frequency by a low-dose X irradiation of Drosophila larvae and possible involvement of DNA single-strand damage repair. Koana T, et al. Radiat Res, 2012 Mar. PMID 22103273
  5. A U-shaped dose-response relationship between x radiation and sex-linked recessive lethal mutation in male germ cells of Drosophila. Koana T, et al. Radiat Res, 2010 Jul. PMID 20681798

See all (155) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HDM, MEI-9, MUS312, and ERCC1 form a complex that resolves meiotic recombination intermediates into crossovers.
    Title: Drosophila hold'em is required for a subset of meiotic crossovers and interacts with the dna repair endonuclease complex subunits MEI-9 and ERCC1.
  2. These results support a model in which MEI-9 nicks Holliday junctions to generate crossovers during meiotic recombination, and, in the absence of MEI-9 activity, the double Holliday junction intermediate instead undergoes dissolution.
    Title: Heteroduplex DNA in meiotic recombination in Drosophila mei-9 mutants.
  3. Drosophila mei-9 has roles in DNA repair and recombination, as shown by mutational analysis
    Title: Mutational analysis of the Drosophila DNA repair and recombination gene mei-9.
  4. MUS312 facilitates resolution of meiotic Holliday junction intermediates by MEI-9
    Title: Drosophila MUS312 interacts with the nucleotide excision repair endonuclease MEI-9 to generate meiotic crossovers.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA recombination TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in nucleotide-excision repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in resolution of meiotic recombination intermediates IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of nucleotide-excision repair factor 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
meiotic 9
Names
CG3697-PA
CG3697-PB
mei-9-PA
mei-9-PB
meiotic-9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4314230..4318801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080329.3 → NP_525068.1  meiotic 9, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24087, Q8IHB9, Q9W4L3
    UniProtKB/TrEMBL
    T2FFI3
    Related
    FBpp0070624
    Conserved Domains (2) summary
    TIGR00596
    Location:122 → 923
    rad1; DNA repair protein (rad1)
    pfam02732
    Location:700 → 832
    ERCC4; ERCC4 domain

  2. NM_001297930.1 → NP_001284859.1  meiotic 9, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284859.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24087, Q8IHB9, Q9W4L3
    UniProtKB/TrEMBL
    T2FFI3
    Conserved Domains (2) summary
    TIGR00596
    Location:122 → 923
    rad1; DNA repair protein (rad1)
    pfam02732
    Location:700 → 832
    ERCC4; ERCC4 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24087.2 Q24087
T2FFI3 T2FFI3

Gene LinkOut

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